Recombinant Mouse Crumbs homolog 1 (Crb1), partial

中文名稱：

Recombinant Mouse Crumbs homolog 1(Crb1) ,partial
貨號：

CSB-YP855357MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Crumbs homolog 1(Crb1) ,partial
貨號：

CSB-EP855357MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Crumbs homolog 1(Crb1) ,partial
貨號：

CSB-EP855357MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Crumbs homolog 1(Crb1) ,partial
貨號：

CSB-BP855357MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Crumbs homolog 1(Crb1) ,partial
貨號：

CSB-MP855357MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Crb1
Uniprot No.：

Q8VHS2
別名：

Crb1; Protein crumbs homolog 1
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion.; May play a role in epidermal tissue morphogenesis. May function in cell attachment for stratified epithelial organization.
基因功能參考文獻：
1. This study showed that The geographic distribution of subretinal microglia/macrophages changes with age in both Crb1 rd8/rd8 and C57BL mice, but the total number of microglia only increases in Crb1 rd8/rd8 mice,and pro-inflamatory phenotype. PMID: 25588310
2. The retinal phenotype of Grk1-/- mice is compromised by a Crb1 rd8 mutation. PMID: 26664249
3. Presence of rd8 (Crb1) mutation does not alter the ocular phenotype of late-onset retinal degeneration mouse model carrying the Ctrp5 mutation. PMID: 25814825
4. Results show that Crb1rd8/rd8 mutation is necessary, but not sufficient for the development of all the degenerative features. PMID: 25147295
5. Study showed that CRB1 and CRB2 in human retinas have an opposite pattern of expression in Muller glia and photoreceptor cells compared with mouse retinas, and that Crb2 influences the severity of the murine Crb1-linked retinal dystrophies. PMID: 24565864
6. These findings suggest that CRB1 and CRB2 suppress late progenitor pool expansion by regulating multiple proliferative signaling pathways. PMID: 24339791
7. The C57BL/6NJ-Crb1(rd8) mutation and its associated retinal phenotypes were corrected efficiently by TALEN-mediated homology-directed repair. PMID: 24346171
8. This study demonistrated that the Rd8 mutation in the Crb1 gene of CD11c-eYFP transgenic reporter mice results in abnormal numbers of CD11c-positive cells in the retina. PMID: 23860032
9. Data show the deletion of Pals1 leads to the disruption of the apical localization of Crb polarity complex proteins Crb1, Crb2 and Crb3 in retinal progenitors and the adult retina. PMID: 22398208
10. CRB1 mutations lead to early-onset severe loss of vision with thickened, disorganized, nonseeing retina. Impaired peripheral vision can persist in late disease stages. PMID: 21757580
11. Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain. PMID: 11744384
12. During light exposure Crb1 is essential to maintain, but not assemble, adherens junctions between photoreceptors and Muller glia cells and prevents retinal disorganization and dystrophy. PMID: 15316081
13. RNA interference-induced silencing of the Crb1-interacting-protein Pals1 (protein associated with Lin7; Mpp5) in Muller glial cells resulted in loss of Crb1, Crb2, Mupp1 and Veli3 protein localization and partial loss of Crb3. PMID: 16885194
14. The extracellular domain of Crb1 positively regulates pituitary tumor transforming gene 1 (Pttg1) transcript levels. PMID: 17234588
15. We propose that Crb1 is required to regulate number and size of these Muller glia cell villi. The subsequent loss of retinal integrity resulted in neovascularization, in which blood vessels of the choroid protruded into the neural retina. PMID: 17705196
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相關疾病：

Defects in Crb1 are a cause of focal retinal dysplasia and degeneration associated with a shortening of inner and outer segments. Affected mice produce a secreted truncated protein that lacks the single transmembrane and the intracellular domain, and develop irregularities at the outer limiting membrane and loss of photoreceptor cells.
亞細胞定位：

[Isoform 1]: Apical cell membrane; Single-pass type I membrane protein. Secreted. Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment.; [Isoform 3]: Secreted. Cytoplasm. Cell junction, focal adhesion.
蛋白家族：

Crumbs protein family
組織特異性：

[Isoform 1]: Expressed in the kidney, lung, stomach and testis. Expressed in the brain. Expressed in the retina of the eye. Expressed in the outer nuclear layer, photoreceptor layer and inner nuclear layer of the retina. Expressed in Mueller cell radial p
數據庫鏈接：

KEGG: mmu:170788

STRING: 10090.ENSMUSP00000060769

UniGene: Mm.95700