Recombinant Mouse Contactin-2 (Cntn2), partial

中文名稱：

Recombinant Mouse Contactin-2(Cntn2) ,partial
貨號：

CSB-YP733782MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Contactin-2(Cntn2) ,partial
貨號：

CSB-EP733782MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Contactin-2(Cntn2) ,partial
貨號：

CSB-EP733782MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Contactin-2(Cntn2) ,partial
貨號：

CSB-BP733782MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Contactin-2(Cntn2) ,partial
貨號：

CSB-MP733782MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Cntn2
Uniprot No.：

Q61330
別名：

Cntn2; TaxContactin-2; Axonal glycoprotein TAG-1; Axonin-1; Transient axonal glycoprotein 1; TAX-1
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region.
基因功能參考文獻：
1. During development, CNTN2 absence can transiently affect the expression levels of myelin and myelin-regulating genes, and results in impaired oligodendrocyte branching and hypomyelination of fiber tracts. During de- and remyelination, Cntn2 absence did not affect oligodendrocyte survival or the extent of remyelination. PMID: 29165835
2. We further demonstrate that Cre expression initiates after birth with preservation of native Cntn2 protein. Finally, we show that Cntn23'UTR-IRES-Cre-EGFP/+ mice maintain normal cardiac mechanical and electrical function. PMID: 28358866
3. Tag1 is crucial for the olfactory circuit formation in mice. PMID: 26525675
4. Interaction proteomics revealed the interactors of Caspr2, including CNTN2, KCNAs, members of the ADAM family (ADAM22, ADAM23 and ADAM11), members of LGI family and MAGUKs (DLGs and MPPs). PMID: 25707359
5. Our results clearly demonstrate that mouse and human contactin-2 are physiological substrates for BACE1 PMID: 24405708
6. the TAG-1-mediated cell-to-cell interaction between the unpolarized multipolar cells and the pioneering axons regulates the polarization of multipolar cells partly through Lyn kinase and Rac1 PMID: 24559674
7. This study demonistrated that knockdown of the cell-surface molecule TAG-1 resulted in retraction of neocortical progenitors' basal processes. PMID: 24056697
8. These results suggest that the Tax-induced decline in p53 function, which is independent of NF-kappaB activation in the early stage, might be the first stage in the onset of ATLL. PMID: 23633516
9. two novel genes, Cntnap2 and Tag1, are implicated in the regulation of diet-induced obesity. PMID: 22752552
10. These observations identify a novel role for TAG1 in modulating the intracellular sorting of signaling receptor complexes. PMID: 22836270
11. These findings are consistent with a regulatory role for Tag-1 in axon emergence as well as migratory behavior by developing mouse cerebellar granule neurons. PMID: 21191645
12. Data show that TAG1 and F3 act antagonistically to control SHH-induced proliferation: F3 suppresses SHH-induced GNP proliferation and induces differentiation, whereas TAG1 antagonises F3. PMID: 21205796
13. Ultrastructural and behavioral analysis of Tag-1 knockout mice shows that the expression of glial TAG-1 is sufficient to restore the axonal and myelin deficits PMID: 20962216
14. These findings suggest that an age-related reduction of TAG-1 expression may predispose neurons to cell death, induced by the binding of TGFbeta2 to APP. PMID: 20184861
15. Although several aspects of the role of TAG-1 in developing sensory axons are consistent with the defects seen in Brn3a knockout mice, it is unlikely that changes in TAG-1 expression directly mediate these defects. PMID: 12598723
16. In the absence of TAG-1, axonal Caspr2 did not accumulate at juxtaparanodes, and shaker-type K+ channels in these regions were severely disrupted, in the central and peripheral nervous systems. PMID: 12975355
17. The TAX-1 upstream sequence includes elements not only sufficient to restrict expression to the nervous system, but also to recapitulate to a great extent the endogenous pattern of the TAG-1 expression in the developing CNS. PMID: 14559358
18. TAG-1 function is required for survival of the neurons of some precerebellar nuclei, while it is not required for cortical interneuron migration in vivo. PMID: 16225856
19. a TAG1-APP signalling pathway negatively modulates neurogenesis through Fe65 PMID: 18278038
20. TAG-1 modulates responses of sensory axons to diffusible guidance signals. PMID: 18550718
21. TAG-1 is an essential regulator of the structure of RGC axons and their surrounding glial cells in the optic nerve. PMID: 18650339
22. Data show that Tag-1(-/-) mice had shorter internodes in the cerebral and cerebellar white matter, and suggest that these detected molecular alterations may account for the behavioural deficits and hyperexcitability in these animals. PMID: 18760366
顯示更多

收起更多
亞細胞定位：

Cell membrane; Lipid-anchor, GPI-anchor.
蛋白家族：

Immunoglobulin superfamily, Contactin family
數據庫鏈接：

KEGG: mmu:21367

STRING: 10090.ENSMUSP00000083707

UniGene: Mm.260861