Recombinant Mouse COP9 signalosome complex subunit 2 (Cops2)

中文名稱：

Recombinant Mouse COP9 signalosome complex subunit 2(Cops2)
貨號：

CSB-YP005789MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse COP9 signalosome complex subunit 2(Cops2)
貨號：

CSB-EP005789MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse COP9 signalosome complex subunit 2(Cops2)
貨號：

CSB-EP005789MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse COP9 signalosome complex subunit 2(Cops2)
貨號：

CSB-BP005789MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse COP9 signalosome complex subunit 2(Cops2)
貨號：

CSB-MP005789MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Cops2
Uniprot No.：

P61202
別名：

Cops2; Csn2; Trip15COP9 signalosome complex subunit 2; SGN2; Signalosome subunit 2; Alien homolog; JAB1-containing signalosome subunit 2; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達區域：

1-443
氨基酸序列

MSDMEDDFMC DDEEDYDLEY SEDSNSEPNV DLENQYYNSK ALKEDDPKAA LSSFQKVLEL EGEKGEWGFK ALKQMIKINF KLTNFPEMMN RYKQLLTYIR SAVTRNYSEK SINSILDYIS TSKQMDLLQE FYETTLEALK DAKNDRLWFK TNTKLGKLYL EREEYGKLQK ILRQLHQSCQ TDDGEDDLKK GTQLLEIYAL EIQMYTAQKN NKKLKALYEQ SLHIKSAIPH PLIMGVIREC GGKMHLREGE FEKAHTDFFE AFKNYDESGS PRRTTCLKYL VLANMLMKSG INPFDSQEAK PYKNDPEILA MTNLVSAYQN NDITEFEKIL KTNHSNIMDD PFIREHIEEL LRNIRTQVLI KLIKPYTRIH IPFISKELNI DVADVESLLV QCILDNTIHG RIDQVNQLLE LDHQKRGGAR YTALDKWTNQ LNSLNQAVVS KLA
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
基因功能參考文獻：
1. Cops2, but not the whole COP9 signalosome, is essential for pluripotency maintenance in mouse embryonic stem cells. Down-regulation of Cops2 reduces expression of pluripotency genes, slows proliferation rate, arrests G2/M cell cycle, and compromises ESC embryoid differentiation. Cops2 binds to Nanog protein and prevents degradation. Cops2 functions as transcriptional corepressor to facilitate pluripotency maintenance. PMID: 27226076
2. these data indicate that Alien/ESET complex is involved in TRbeta1-mediated transcription repression of E2F1 and provide a molecular basis of thyroid hormone-induced repression of proliferation. PMID: 22079090
3. Nif3l1 participates in neural differentiation of P19 cells through cooperation with Trip15/CSN2. PMID: 12522100
4. Expressed at an early stage of neuronal differentiation of P19 embryonal carcinoma cells. PMID: 12524175
5. Disruption of Cops2 causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death. PMID: 12972599
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亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

CSN2 family
組織特異性：

Widely expressed in embryonic, fetal and adult tissues, except cartilage and smooth muscle.
數據庫鏈接：

KEGG: mmu:12848

STRING: 10090.ENSMUSP00000028635

UniGene: Mm.3596