Recombinant Mouse Beta-defensin 14 (Defb14)

中文名稱：

Recombinant Mouse Beta-defensin 14(Defb14)
品名簡稱：

Recombinant Mouse Defb14 protein
貨號：

CSB-EP749254MO
說明書：

MSDS Datasheet
規格：

￥1836
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

Defb14
Uniprot No.：

Q7TNV9
別名：

Defb14; Beta-defensin 14; BD-14; mBD-14; Defensin; beta 14
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
來源：

E.coli
分子量：

21.2kDa
表達區域：

23-67aa
氨基酸序列

FLPKTLRKFFCRIRGGRCAVLNCLGKEEQIGRCSNSGRKCCRKKK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-SUMO-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Has antibacterial activity.
基因功能參考文獻：
1. this work demonstrates that mouse beta-defensin-14 can promote the maturation of dendritic cells in which TLR-4 is possibly involved PMID: 29253819
2. This study indicated that the potential antibacterial role of increased MBD-14 in the osteomyelitis mouse model. PMID: 24489798
3. BD14 expression by tumor-infiltrating host cells results in chemoattraction of CCR6-positive B220-positive lymphocytes, which in turn initiates a proangiogenic pathway leading to enhanced angiogenesis and organized tumor tissue development. PMID: 22504651
4. Murine beta-defensin-14, like ultraviolet radiation (UVR), can shift surface marker expression of CD4+CD25- T cells toward a regulatory (Treg) phenotype but does not appear to play a major role in UVR-induced immunosuppression. PMID: 22174455
5. beta-defensin 4 and 14 contribute to the innate and adaptive immune response in their role as chemoattractants PMID: 20483750
6. both hBD3 and mBD14 were chemotactic for freshly isolated mouse resident peritoneal cells. Thus, mBD14, based on structural and functional similarities, appears to be an orthologue of hBD3. PMID: 18167348
7. chemoattractant and antimicrobial activities of beta-defensins can be separated, and both of these functions are independent of intramolecular disulfide bonds PMID: 18180295
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亞細胞定位：

Secreted.
蛋白家族：

Beta-defensin family
數據庫鏈接：

KEGG: mmu:244332

STRING: 10090.ENSMUSP00000062781

UniGene: Mm.358923