Recombinant Mouse Ataxin-1-like (Atxn1l)

中文名稱：

Recombinant Mouse Ataxin-1-like(Atxn1l)
貨號：

CSB-YP002440MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Ataxin-1-like(Atxn1l)
貨號：

CSB-EP002440MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Ataxin-1-like(Atxn1l)
貨號：

CSB-EP002440MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Ataxin-1-like(Atxn1l)
貨號：

CSB-BP002440MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Ataxin-1-like(Atxn1l)
貨號：

CSB-MP002440MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Atxn1l
Uniprot No.：

P0C7T6
別名：

Atxn1l; BoatAtaxin-1-like; Brother of ataxin-1
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達區域：

1-687
氨基酸序列

MKPVHERSQE CLPPKKRDLP VTSEDMGRTT SCSTNHTPSS DASEWSRGVV VAGQSQTGAR VSLGGDGTEA ITGLTVDQYG MLYKVAVPPA TFSPTGLPSV VNMSPLPPTF NVASSLIQHP GIHYPPVHYA QLPSTSLQFI GSPYSLPYAV PPNFLPSPLL SPSANLATTH LPHFVPYASL LAEEATPPPQ AASPAQSFNK SSSATSPPGQ LPHHSNTQPL DLAPGRMPIY YQMSRLPAGY TLHETSTAGA SPILTPQEGQ SALEAAAANG QRQRERNVRR ESEALDSASS KGESQGLVPV VECMADGQLF SGSQTPRVEV AAPAHRGTPD TDLEVQRVVG ALASQDYRVV AAQRKDEPSP LNLSHHNLDH QGEGRGSARN PTELVEKSQA RVFYPQSHQE PVKHRPLPKA MVVANGNLVP TGTDPSLLPV GSEILVASSL DLQARATFPD KEPTPPPVTS SHLPSHFMKG AIIQLATGEL KRVEDLQTQD FVRSAEVSGG LKIDSSTVVD IQESQWPGFV MLHFVVGEQQ SKVSIEVPPE HPFFVYGQGW SSCSPGRTAQ LFSLPCHRLQ VGDVCISISL QSLNSNSVSQ ASCAPPGQLG TPRERPERTV LGPRDLCDSE GKNQPSGEGS RVGEPSQPEP GAQACWPAPS FQRFSMQGEE ARAAMLRPSF IPQEVKLSIE GRSNAGK
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress the cytotoxicity of ATXN1 in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development.
基因功能參考文獻：
1. Boat is an in vivo binding partner of ataxin-1 whose altered expression in Purkinje cells may contribute to their degeneration in causes spinocerebellar ataxia type 1 animals PMID: 16121196
2. Results provide genetic evidence that the selective neuropathology of Spinocerebellar ataxia type 1 arises from modulation of a core functional activity of ataxin-1 PMID: 17322884
亞細胞定位：

Nucleus. Cell projection, dendrite. Note=Forms nuclear foci. Colocalizes with NCOR2 and HDAC3. Distributed beyond the nucleus into the cell body and dendrites in Purkinje cells and in inferior olive cells.
蛋白家族：

ATXN1 family
組織特異性：

Expressed in the cortex and hypothalamus (at protein level). Expressed in neuronal cells. Highly expressed in Purkinje cells of cerebellum.
數據庫鏈接：

KEGG: mmu:52335

STRING: 10090.ENSMUSP00000090850

UniGene: Mm.276770