Recombinant Mouse Asc-type amino acid transporter 1 (Slc7a10), partial

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中文名稱：

小鼠Slc7a10重組蛋白
品名簡稱：

Recombinant Mouse Slc7a10 protein, partial
貨號：

CSB-YP021710MO
說明書：

MSDS Datasheet
規格：

￥1500
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

Slc7a10
Uniprot No.：

P63115
別名：

Slc7a10; Asc1; Asc-type amino acid transporter 1; Asc-1; D-serine transporter; Solute carrier family 7 member 10
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
來源：

Yeast
分子量：

22.5kDa
蛋白標簽：

N-terminal His-tagged/Tag-Free
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Sodium-independent, high affinity transport of small neutral D- and L-amino acids and amino acid-related compounds. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse.
基因功能參考文獻：
1. this study shows that the astrocytic transporter SLC7A10 mediates glycinergic inhibition of spinal cord motor neurons PMID: 27759100
2. Asc-1 has a novel role in regulating NMDA receptor-dependent synaptic activity by mediating concurrent non-vesicular release of D-serine and glycine. PMID: 23426681
3. The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission PMID: 25755256
4. The amino acid transporter ASC-1 is a white adipocyte-specific cell surface protein. PMID: 25080478
5. Lack of the alanine-serine-cysteine transporter 1 causes tremors, seizures, and early postnatal death in mice. PMID: 16026768
6. The results presented reveal that Asc-1 is the only high affinity D-serine transporter in the mouse CNS and is the predominant mechanism for D-serine reuptake. PMID: 17432963
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亞細胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

Amino acid-polyamine-organocation (APC) superfamily
組織特異性：

Highly expressed in brain and lung, and to a lesser extent in placenta and small intestine.
數據庫鏈接：

KEGG: mmu:53896

STRING: 10090.ENSMUSP00000001854

UniGene: Mm.35567