Recombinant Mouse Ameloblastin (Ambn)

中文名稱：

Recombinant Mouse Ameloblastin(Ambn)
貨號：

CSB-YP001653MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Ameloblastin(Ambn)
貨號：

CSB-EP001653MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Ameloblastin(Ambn)
貨號：

CSB-EP001653MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Ameloblastin(Ambn)
貨號：

CSB-BP001653MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Ameloblastin(Ambn)
貨號：

CSB-MP001653MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ambn
Uniprot No.：

O55189
別名：

AmbnAmeloblastin
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

27-407
氨基酸序列

VPAF PQQPGAQGMA PPGMASLSLE TMRQLGSLQG LNALSQYSRL GFGKALNSLW LHGLLPPHNS FPWIGPREHE TQQPSLQPHQ PGLKPFLQPT AATGVQVTPQ KPGPQPPMHP GQLPLQEGEL IAPDEPQVAP SENPPTPEVP IMDFADPQFP TVFQIARSIS RGPMAHNKAS AFYPGMFYMS YGANQLNAPA RIGFMSSEEM PGERGSPMAY GTLFPRFGGF RQTLRRLNQN SPKGGDFTVE VDSPVSVTKG PEKGEGPEGS PLQEANPGKR ENPALLSQMA PGAHAGLLAF PNDHIPSMAR GPAGQRLLGV TPAAADPLIT PELAEVYETY GADVTTPLGD GEATMDITMS PDTQQPLLPG NKVHQPQVHN AWRFQEP
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Involved in the mineralization and structural organization of enamel.
基因功能參考文獻：
1. Data demonstrate the functional importance of the AMBN extracellular matrix protein in bone fracture prevention and rapid fracture healing. PMID: 26899203
2. AMBN facilitates rapid long bone growth and an important growth spurt during the skeletogenesis of adolescent tooth-bearing vertebrates PMID: 26766111
3. Protein interaction between Ambn and Psma3 can facilitate redistribution of ameloblastin domains within forming enamel. PMID: 26070558
4. AMBN may function as a growth factor-like molecule solubilized in the aqueous microenvironment. In jaws, it might play a role in bone physiology through autocrine/paracrine pathways, particularly during development and stress-induced remodeling. PMID: 24933156
5. Ameloblastin (AMBN) expression may be regulated in a site-specific manner and identify AMBN as a putative in vivo marker of the site-specific fingerprint of bone organs PMID: 25158194
6. Ambn plays a crucial role in the regulation of cranial bone growth and suture closure via Msx 2 suppression and proliferation inhibition. PMID: 23593111
7. Blocking integrin alpha2beta1 and ERK 1/2 pathways alleviated the effects of AMBN on osteoclast differentiation. PMID: 23385480
8. ERP expression follows defined developmental profiles; affects osteoblast differentiation, mineralization, calvarial bone development. with role in developing enamel matrix, ERPs retain conserved function related to bone biomineralization. PMID: 23625374
9. AMBN may regulate differentiation state of Hertwig's epithelial root sheath-derived cells and its expression fuctions as a trigger for normal root formation. PMID: 23372724
10. All lines expressing detectable levels of ameloblastin at least partially recovered the enamel phenotype. Ameloblastin is essential for dental enamel formation. PMID: 20940352
11. study may implicate the role of the ameloblastin gene locus in the etiology of a number of undiagnosed autosomally dominant cases of amelogenesis imperfecta PMID: 12657627
12. Ameloblastin is a cell adhesion molecule essential for amelogenesis, and it plays a role in maintaining the differentiation state of secretory stage ameloblasts by binding to ameloblasts and inhibiting proliferation. PMID: 15583034
13. Ameloblastin is an important regulator to maintain the differentiation state of ameloblasts. PMID: 16612084
14. no mutation could be detected in the ameloblastin gene [in amelogenesis imperfecta] PMID: 17652207
15. the ameloblastin 37-kDa isoform interacts with amelogenin during early tooth development. PMID: 17921454
16. Results indicate that absence of full-length ameloblastin and/or expression of an incomplete protein have direct/indirect effects beyond structuring of mineral during enamel formation. PMID: 19375505
17. Enamel matrix proteins such as amelogenins and ameloblastin are not only required for the formation of a proper matrix for well-orchestrated enamel biomineralization, but also have synergistic cellular functions during enamel development. PMID: 19407150
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亞細胞定位：

Secreted, extracellular space, extracellular matrix.
蛋白家族：

Ameloblastin family
組織特異性：

Ameloblast-specific.
數據庫鏈接：

KEGG: mmu:11698

STRING: 10090.ENSMUSP00000031226

UniGene: Mm.8437