Recombinant Mouse Adipolin (C1qtnf12)

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品名簡稱：

Recombinant Mouse C1qtnf12 protein
貨號：

CSB-BP840280MO
說明書：

MSDS Datasheet
規格：

￥3168
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

純度：

Greater than 85% as determined by SDS-PAGE.
基因名：

C1qtnf12
Uniprot No.：

Q8R2Z0
別名：

(Adipose-derived insulin-sensitizing factor)(Complement C1q tumor necrosis factor-related protein 12)(Adipolin fCTRP12)(Adipolin full-length form)(Adipolin cleaved form)(Adipolin gCTRP12)
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
來源：

Baculovirus
分子量：

33.9 kDa
表達區域：

22-308aa
氨基酸序列

RQELKKSRQLFARVDSPNITTSNREGFPGSVKPPEASGPELSDAHMTWLNFVRRPDDGSSRKRCRGRDKKSRGLSGLPGPPGPPGPPGPPGSPGVGVTPEALLQEFQEILKEATELRFSGLPDTLLPQEPSQRLVVEAFYCRLKGPVLVDKKTLVELQGFQAPTTQGAFLRGSGLSLSLGRFTAPVSAIFQFSASLHVDHSELQGRGRLRTRDMVRVLICIESLCHRHTSLEAVSGLESNSRVFTVQVQGLLHLQSGQYVSVFVDNSSGAVLTIQNTSSFSGMLLGT
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

C-terminal 6xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue.; Acts by activating the Akt signaling in hepatocytes and adipocytes. Not able to increase insulin-stimulated glucose uptake in adipocytes.; Acts by activating the MAP kinase. Increases insulin-stimulated glucose uptake in adipocytes.
基因功能參考文獻：
1. Loss of a single Ctrp12 allele affects glucose and lipid metabolism. PMID: 27815536
2. mRNA expression of Fam132a, which encodes a newly identified insulin-sensitizing adipokine, adipolin, is significantly upregulated in the absence of KLF3. PMID: 23633521
3. These data suggest that obesity states facilitate the cleavage of adipolin presumably through upregulation of furin in adipose tissue. PMID: 23068097
4. The aim of this study was to demonstrate adipolin expression in human and murine chondrocytes and to elucidate the intracellular mechanism involved in adipolin basal expression PMID: 22736092
5. Endopeptidase cleavage generates a functionally distinct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity. PMID: 22942287
6. CTRP12 as a novel metabolic regulator linking adipose tissue to whole body glucose homeostasis through insulin-dependent and independent mechanisms. PMID: 22275362
7. Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism PMID: 21849507
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亞細胞定位：

[Adipolin fC1QTNF12]: Secreted.; [Adipolin gC1QTNF12]: Secreted.
蛋白家族：

Adipolin/erythroferrone family
組織特異性：

Widely expressed, with high expression in subcutaneous and epididymal white adipose tissues and brown adipose tissue. Expressed in adipocytes (at protein level).
數據庫鏈接：

KEGG: mmu:67389

STRING: 10090.ENSMUSP00000024338

UniGene: Mm.29140