Recombinant Mouse Active breakpoint cluster region-related protein (Abr), partial

中文名稱：

Recombinant Mouse Active breakpoint cluster region-related protein(Abr) ,partial
貨號：

CSB-YP729186MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Active breakpoint cluster region-related protein(Abr) ,partial
貨號：

CSB-EP729186MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Active breakpoint cluster region-related protein(Abr) ,partial
貨號：

CSB-EP729186MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Active breakpoint cluster region-related protein(Abr) ,partial
貨號：

CSB-BP729186MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Active breakpoint cluster region-related protein(Abr) ,partial
貨號：

CSB-MP729186MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Abr
Uniprot No.：

Q5SSL4
別名：

AbrActive breakpoint cluster region-related protein
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. Functions as an important negative regulator of neuronal RAC1 activity. Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity.
基因功能參考文獻：
1. Loss of abr expression causes defects in spine development. PMID: 24960694
2. These results identify Abr-regulated CD4(+) T cell migration as an important component of severe cockroach allergen-evoked allergic asthma in mice. PMID: 24058174
3. Bcr and Abr play a critical role in down-regulating hypoxia-induced pulmonary hypertension by deactivating Rac1. PMID: 23152932
4. Abr and Bcr play important complementary roles during vestibular morphogenesis PMID: 11921339
5. These results identify Abr and Bcr as the only GTPase-activating proteins to date that specifically negatively regulate Rac function in vivo in primary macrophages. PMID: 17116687
6. These data show that Abr and Bcr normally curb very specific functions of mature tissue innate immune cells. PMID: 19703997
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亞細胞定位：

Cell projection, dendritic spine. Cell projection, axon. Cell junction, synapse.
組織特異性：

In hippocampal subregions, expressed at similarly high levels in the dentate gyrus and CA1 regions, but lower in the CA3 region.
數據庫鏈接：

KEGG: mmu:109934

STRING: 10090.ENSMUSP00000091551

UniGene: Mm.258939