Recombinant Macaca mulatta Leptin receptor (LEPR), partial

中文名稱：

獼猴LEPR重組蛋白
貨號：

CSB-YP012871MOW
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

獼猴LEPR重組蛋白
貨號：

CSB-EP012871MOW
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

獼猴LEPR重組蛋白
貨號：

CSB-EP012871MOW-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

獼猴LEPR重組蛋白
貨號：

CSB-BP012871MOW
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

獼猴LEPR重組蛋白
貨號：

CSB-MP012871MOW
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

LEPR
Uniprot No.：

Q9MYL0
別名：

LEPR; OBRLeptin receptor; LEP-R; OB receptor; OB-R; CD antigen CD295
種屬：

Macaca mulatta (Rhesus macaque)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Receptor for hormone LEP/leptin. On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity. Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production.; May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis. Does not induce phosphorylation of and activate STAT3.
基因功能參考文獻：
1. A 2-day fast increased leptin receptor (Ob-R) expression in the ventromedial nucleus (VMN). PMID: 17124379
亞細胞定位：

Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane.
蛋白家族：

Type I cytokine receptor family, Type 2 subfamily
組織特異性：

Widely expressed. High expression of isoform B in liver, adipose tissue, hypothalamus and choroid plexus.
數據庫鏈接：

KEGG: mcc:574126

UniGene: Mmu.1248