Recombinant Loxosceles reclusa Sphingomyelin phosphodiesterase D LrSicTox-alphaIA1i

中文名稱：

Recombinant Loxosceles reclusa Sphingomyelin phosphodiesterase D LrSicTox-alphaIA1i
貨號：

CSB-YP315999LJF
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Loxosceles reclusa Sphingomyelin phosphodiesterase D LrSicTox-alphaIA1i
貨號：

CSB-EP315999LJF
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Loxosceles reclusa Sphingomyelin phosphodiesterase D LrSicTox-alphaIA1i
貨號：

CSB-EP315999LJF-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Loxosceles reclusa Sphingomyelin phosphodiesterase D LrSicTox-alphaIA1i
貨號：

CSB-BP315999LJF
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Loxosceles reclusa Sphingomyelin phosphodiesterase D LrSicTox-alphaIA1i
貨號：

CSB-MP315999LJF
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

N/A
Uniprot No.：

P0CE78
別名：

Dermonecrotic toxin LrSicTox-alphaIA1i; EC 4.6.1.-; Lr2; Phospholipase D; PLD; SMaseD/LysoPLD; Sphingomyelin phosphodiesterase D 2; SMD 2; SMase D 2; Sphingomyelinase D 2
種屬：

Loxosceles reclusa (Brown recluse spider)
蛋白長度：

full length protein
表達區域：

1-279
氨基酸序列

ANKRPAWIMG HMVNAIYQID EFVNLGANSI ETDVSFDKDA NPEYTYHGVP CDCGRSCLKW EYFSDFLKGL RKATTPGDSK YHAKLVLVVF DLKTGSLYDN QAYDAGKKLA KNLLKHYWNN GNNGGRAYIV LSIPDLNHYK LITGFKETLK SEGHPELMDK VGHDFSGNDA IGDVGNAYKK AGVTGHVWQS DGITNCLLRG LSRVKDAVKN RDSSNGFINK VYYWTVDKRA TTREALDAGV DGVMTNYPDV ITDVLNESAY KAKFRIATYD DNPWETFKN
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate. This toxin acts on sphingomyelin (SM). It also acts on a broad range of lysophospholipids, like lysophosphatidylinositol (LPI), lysophosphatidylglycerol (LPG), lysophosphatidylethanolamine (LPE), lysobisphosphatidic acid (LBPA), lysophosphatidylserine (LPS) and lysophosphatidylcholines (LPC) of varying chain lengths. The substrate preference is LPI > LPG > LPS > LPC >> LPE, LBPA. Furthermore, the enzyme also act on cyclic phosphatidic acid and lyso-platelet activating factor (LPAF, an alkyl-LPC). The enzyme does not act on sphingosylphosphorylcholine (SPC, also known as lyso-sphingomyelin) and PAF. The toxin may also act on ceramide phosphoethanolamine (CPE). It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products. It does not exhibit detectable PLA1/2 activity. It induces dose-dependent hemolysis and dermonecrosis. Also induces increased vascular permeability, edema, inflammatory response, and platelet aggregation.
亞細胞定位：

Secreted.
蛋白家族：

Arthropod phospholipase D family, Class II subfamily
組織特異性：

Expressed by the venom gland.