Recombinant Human adenovirus C serotype 2 Late 100 kDa protein, partial

中文名稱：

Recombinant Human adenovirus C serotype 2 Late 100 kDa protein ,partial
貨號：

CSB-YP335082HIK
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human adenovirus C serotype 2 Late 100 kDa protein ,partial
貨號：

CSB-EP335082HIK
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human adenovirus C serotype 2 Late 100 kDa protein ,partial
貨號：

CSB-EP335082HIK-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human adenovirus C serotype 2 Late 100 kDa protein ,partial
貨號：

CSB-BP335082HIK
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human adenovirus C serotype 2 Late 100 kDa protein ,partial
貨號：

CSB-MP335082HIK
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

L4
Uniprot No.：

P24932
別名：

L4; Shutoff protein; 100 kDa protein; p100K; 100K-chaperone protein; L4-100K; Shutoff protein 100K
種屬：

Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Protein that inhibits host translation while promoting late viral translation by ribosome shunting. Blocks host cap-dependent translation by binding to eIF4G, displacing MKNK1 from cap initiation complexes and preventing EIF4E phosphorylation. Binds to the tripartite leader sequence of viral late mRNAs and recruits host eIF4G, PABPC1/poly-A binding protein and 40S ribosomes subunits on viral mRNAs, allowing ribosome shunting and efficient translation of late viral mRNAs even though conventional translation via ribosome scanning from the cap has been shut off in the host cell. During assembly, acts as a chaperone protein that helps hexon proteins assembly into trimers (Probable).
基因功能參考文獻：
1. The adenovirus L4-22K protein has distinct functions in the posttranscriptional regulation of gene expression and encapsidation of the viral genome. PMID: 23637408
2. the adenovirus L4-22K protein is multifunctional and an integral component of crucial aspects of infect PMID: 22811519
3. Neutralizing antibodies target multiple hexon hypervariable regions. PMID: 22072746
4. findings show that 2 key positive regulators of the major late gene, L4-22K and L4-33K initially are expressed from a novel promoter embedded within the major late gene and dedicated to their expression; this promoter is required for late gene expression PMID: 20444889
5. These results indicate that L4-22K plays a key role in the early-late switch in MLTU expression, additional to and distinct from the role of L4-33K. PMID: 19176628
6. Arginine-to-glycine exchanges in the RGG boxes significantly diminished L4-100K methylation and substantially reduced virus growth. PMID: 19264777
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亞細胞定位：

Host cytoplasm.
蛋白家族：

Adenoviridae shutoff protein family
數據庫鏈接：

KEGG: vg:2653005