Recombinant Human Zinc finger CCHC domain-containing protein 12 (ZCCHC12)

中文名稱：

人ZCCHC12重組蛋白
貨號：

CSB-YP761340HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人ZCCHC12重組蛋白
貨號：

CSB-EP761340HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人ZCCHC12重組蛋白
貨號：

CSB-EP761340HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人ZCCHC12重組蛋白
貨號：

CSB-BP761340HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人ZCCHC12重組蛋白
貨號：

CSB-MP761340HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ZCCHC12
Uniprot No.：

Q6PEW1
別名：

ZCCHC12; SIZN1; Zinc finger CCHC domain-containing protein 12; Smad-interacting zinc finger protein 1
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-402
氨基酸序列

MASIIARVGN SRRLNAPLPP WAHSMLRSLG RSLGPIMASM ADRNMKLFSG RVVPAQGEET FENWLTQVNG VLPDWNMSEE EKLKRLMKTL RGPAREVMRV LQATNPNLSV ADFLRAMKLV FGESESSVTA HGKFFNTLQA QGEKASLYVI RLEVQLQNAI QAGIIAEKDA NRTRLQQLLL GGELSRDLRL RLKDFLRMYA NEQERLPNFL ELIRMVREEE DWDDAFIKRK RPKRSESMVE RAVSPVAFQG SPPIVIGSAD CNVIEIDDTL DDSDEDVILV ESQDPPLPSW GAPPLRDRAR PQDEVLVIDS PHNSRAQFPS TSGGSGYKNN GPGEMRRARK RKHTIRCSYC GEEGHSKETC DNESDKAQVF ENLIITLQEL THTEMERSRV APGEYNDFSE PL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression.
基因功能參考文獻：
1. Our study indicated that ZCCHC12 gene has important biological functions and acts as a metastasis-related oncogene in papillary thyroid cancer PMID: 28424903
2. The ZCCHC12 gene may be a novel diagnostic molecular marker of primary papillary thyroid carcinoma PMID: 21739307
3. data implicate SIZN1 as a candidate gene for X-linked mental retardation and/or as a neurocognitive functional modifier PMID: 18798319
4. Data indicate that the SIMs in Sizn1 are required for its PML-NB localization and for the full transcriptional co-activation function in BMP signaling. PMID: 19416967
5. ZCCHC12 enhanced the transcriptional activities of activator protein 1 (AP-1) and cAMP response element binding protein (CREB) as a coactivator PMID: 19578717
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蛋白家族：

ZCCHC12 family
數據庫鏈接：

HGNC: 27273

OMIM: 300701

KEGG: hsa:170261

STRING: 9606.ENSP00000308921

UniGene: Hs.21417