Recombinant Human TLR adapter interacting with SLC15A4 on the lysosome (TASL)

中文名稱：

Recombinant Human TLR adapter interacting with SLC15A4 on the lysosome (TASL)
貨號：

CSB-YP867184HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human TLR adapter interacting with SLC15A4 on the lysosome (TASL)
貨號：

CSB-EP867184HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human TLR adapter interacting with SLC15A4 on the lysosome (TASL)
貨號：

CSB-BP867184HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human TLR adapter interacting with SLC15A4 on the lysosome (TASL)
貨號：

CSB-MP867184HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

CXorf21
Uniprot No.：

Q9HAI6
別名：

CXorf21Protein CXorf21
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-301
氨基酸序列

MLSEGYLSGL EYWNDIHWSC ASYNEQVAGE KEEETNSVAT LSYSSVDETQ VRSLYVSCKS SGKFISSVHS RESQHSRSQR VTVLQTNPNP VFESPNLAAV EICRDASRET YLVPSSCKSI CKNYNDLQIA GGQVMAINSV TTDFPSESSF EYGPLLKSSE IPLPMEDSIS TQPSDFPQKP IQRYSSYWRI TSIKEKSSLQ MQNPISNAVL NEYLEQKVVE LYKQYIMDTV FHDSSPTQIL ASELIMTSVD QISLQVSREK NLETSKARDI VFSRLLQLMS TEITEISTPS LHISQYSNVN P
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5 transcription factor via its pLxIS motif, leading to IRF5 activation and subsequent expression of type I interferons. Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes.
亞細胞定位：

Lysosome membrane. Endosome membrane. Nucleus. Cytoplasm.
組織特異性：

Highly expressed in immune cell types such as B-cells, neutrophils, dendritic cells and monocytes, the expression levels are two-three-fold higher in female cells compared to male cells (at protein level). Expressed at low levels in T-cells and NK cells.
數據庫鏈接：

HGNC: 25667

KEGG: hsa:80231

STRING: 9606.ENSP00000368245

UniGene: Hs.665009