Product Name: Recombinant Human Inositol polyphosphate-5-phosphatase A (INPP5A)

中文名稱：

人INPP5A重組蛋白
貨號：

CSB-YP622780HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人INPP5A重組蛋白
貨號：

CSB-EP622780HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人INPP5A重組蛋白
貨號：

CSB-BP622780HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人INPP5A重組蛋白
貨號：

CSB-MP622780HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

INPP5A
Uniprot No.：

Q14642
別名：

4; 43 kDa inositol polyphosphate 5-phophatase; 5-trisphosphate 5-phosphatase; 5PTase; CTCL tumor antigen HD-CL-02; DKFZp434A1721; I5P1; I5P1_HUMAN; Inositol polyphosphate 5 phosphatase; inositol polyphosphate-5-phosphatase A; inositol trisphosphate-5-phosphatase; INPP5A; INPP5A inositol polyphosphate-5-phosphatase; InsP3 5-phosphatase; MGC116947; MGC116949; Type I inositol-1; type I inositol-1,4,5-trisphosphate 5-phophatase
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區域：

1-409
氨基酸序列

MAGKAAAPGT AVLLVTANVG SLFDDPENLQ KNWLREFYQV VHTHKPHFMA LHCQEFGGKN YEASMSHVDK FVKELLSSDA MKEYNRARVY LDENYKSQEH FTALGSFYFL HESLKNIYQF DFKAKKYRKV AGKEIYSDTL ESTPMLEKEK FPQDYFPECK WSRKGFIRTR WCIADCAFDL VNIHLFHDAS NLVAWETSPS VYSGIRHKAL GYVLDRIIDQ RFEKVSYFVF GDFNFRLDSK SVVETLCTKA TMQTVRAADT NEVVKLIFRE SDNDRKVMLQ LEKKLFDYFN QEVFRDNNGT ALLEFDKELS VFKDRLYELD ISFPPSYPYS EDARQGEQYM NTRCPAWCDR ILMSPSAKEL VLRSESEEKV VTYDHIGPNV CMGDHKPVFL AFRIMPGAGK PHAHVHKCC
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate. Plays a crucial role in the survival of cerebellar Purkinje cells.
基因功能參考文獻：
1. the overexpression of miR-181a-5p enhanced cell proliferation and invasion and inhibited apoptosis of cervical cancer cells by negatively targeting INPP5A PMID: 28653606
2. The ataxic phenotype and characteristics neurodegeneration of the Inpp5a Gt(OST50073)Lex mouse indicate a crucial role for Inpp5a in purkinje cells survival. PMID: 26051944
3. NPP5Amay play a role in development and progression of cutaneous squamous cell carcinoma tumors PMID: 20876729
亞細胞定位：

Cell membrane; Lipid-anchor. Cell projection, dendrite.
蛋白家族：

Inositol 1,4,5-trisphosphate 5-phosphatase type I family
組織特異性：

Predominantly expressed in heart, brain, and skeletal muscle. In brain; high level in Purkinje cells.
數據庫鏈接：

HGNC: 6076

OMIM: 600106

KEGG: hsa:3632

STRING: 9606.ENSP00000357583

UniGene: Hs.523360