Recombinant Human Tumor necrosis factor alpha-induced protein 2 (TNFAIP2)

中文名稱：

人TNFAIP2重組蛋白
貨號：

CSB-YP023957HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人TNFAIP2重組蛋白
貨號：

CSB-EP023957HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人TNFAIP2重組蛋白
貨號：

CSB-EP023957HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人TNFAIP2重組蛋白
貨號：

CSB-BP023957HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人TNFAIP2重組蛋白
貨號：

CSB-MP023957HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

TNFAIP2
Uniprot No.：

Q03169
別名：

B94; EXOC3L3; exocyst complex component 3-like 3; Primary response gene B94 protein; TNAP2_HUMAN; TNF alpha-induced protein 2; Tnfaip2; tumor necrosis factor alpha induced protein 2; Tumor necrosis factor alpha-induced protein 2; tumor necrosis factor, alpha-induced protein 2
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區域：

1-654
氨基酸序列

MSEASSEDLV PPLEAGAAPY REEEEAAKKK KEKKKKSKGL ANVFCVFTKG KKKKGQPSSA EPEDAAGSRQ GLDGPPPTVE ELKAALERGQ LEAARPLLAL ERELAAAAAA GGVSEEELVR RQSKVEALYE LLRDQVLGVL RRPLEAPPER LRQALAVVAE QEREDRQAAA AGPGTSGLAA TRPRRWLQLW RRGVAEAAEE RMGQRPAAGA EVPESVFLHL GRTMKEDLEA VVERLKPLFP AEFGVVAAYA ESYHQHFAAH LAAVAQFELC ERDTYMLLLW VQNLYPNDII NSPKLVGELQ GMGLGSLLPP RQIRLLEATF LSSEAANVRE LMDRALELEA RRWAEDVPPQ RLDGHCHSEL AIDIIQITSQ AQAKAESITL DLGSQIKRVL LVELPAFLRS YQRAFNEFLE RGKQLTNYRA NVIANINNCL SFRMSMEQNW QVPQDTLSLL LGPLGELKSH GFDTLLQNLH EDLKPLFKRF THTRWAAPVE TLENIIATVD TRLPEFSELQ GCFREELMEA LHLHLVKEYI IQLSKGRLVL KTAEQQQQLA GYILANADTI QHFCTQHGSP ATWLQPALPT LAEIIRLQDP SAIKIEVATY ATCYPDFSKG HLSAILAIKG NLSNSEVKRI RSILDVSMGA QEPSRPLFSL IKVG
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

May play a role as a mediator of inflammation and angiogenesis.
基因功能參考文獻：
1. A polarized secretion assay suggested that the silencing of endothelial myeloid-secretory impairs T effector transendothelial migration by reducing the preferential secretion of endothelial-produced CCL2. PMID: 26701136
2. Data indicate that TNFAIP2 overexpression may facilitate proliferation and metastasis via activation of the Wnt/beta-catenin signaling pathway in esophageal squamous cell carcinoma. PMID: 28393234
3. Taken together, genome-wide chromatin analysis of Legionella pneumophila-infected macrophages demonstrated induction of TNFAIP2, a NF-kappaB-dependent factor relevant for bacterial replication. PMID: 27130431
4. data suggest that TNFAIP2 is a novel inhibitor of NF-kappa-B that acts as an autoinhibitor of the TNFalpha response during septic shock. PMID: 26347487
5. findings collectively suggest that TNFAIP2 is a direct KLF5 target gene, and both KLF5 and TNFAIP2 promote breast cancer cell proliferation, migration and invasion through Rac1 and Cdc42 PMID: 26189798
6. A functional TNFAIP2 3'-UTR rs8126 genetic polymorphism contributes to risk of esophageal squamous cell carcinoma. PMID: 25383966
7. the regulation of TNFAIP2 and its role in promoting NPC tumor progression PMID: 23975427
8. The TNFAIP2 miRNA binding site rs8126 T>C single nucleotide polymorphism may be a marker for susceptibility to gastric cancer. PMID: 23724109
9. A functional variant at the miR-184 binding site in TNFAIP2 is associated with squamous cell carcinoma of the head and neck. PMID: 21934093
10. TNFAIP2 may serve as a useful new marker of dendritic and histiocytic sarcomas. PMID: 21921781
11. TNFAIP2 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
12. TNFAIP2 is a cell migration-promoting protein and its expression predicts distant metastasis. Our data suggest that TNFAIP2 may serve as an independent prognostic indicator for nasopharyngeal carcinoma. PMID: 21057457
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蛋白家族：

SEC6 family
數據庫鏈接：

HGNC: 11895

OMIM: 603300

KEGG: hsa:7127

STRING: 9606.ENSP00000332326

UniGene: Hs.525607