Recombinant Human Tubulin beta-4B chain (TUBB4B)

中文名稱：

人TUBB4B重組蛋白
貨號：

CSB-YP025322HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人TUBB4B重組蛋白
貨號：

CSB-EP025322HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人TUBB4B重組蛋白
貨號：

CSB-EP025322HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人TUBB4B重組蛋白
貨號：

CSB-BP025322HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人TUBB4B重組蛋白
貨號：

CSB-MP025322HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

TUBB4B
Uniprot No.：

P68371
別名：

bA506K6.1; beta 2 tubulin; Beta2; class II beta tubulin isotype; class IIa beta-tubulin; class IIb beta-tubulin; Class IVb beta tubulin; dJ40E16.7; DKFZp566F223; FLJ98847; M(beta)2; MGC8685; OTTHUMP00000015956; OTTHUMP00000015964; TBB4B_HUMAN; TUBB 2; TUBB 2A; TUBB 2C; TUBB; TUBB PARALOG; TUBB2; TUBB2A; TUBB2B; TUBB2C; Tubb4b; Tubulin beta 2; Tubulin beta 2 chain; Tubulin beta 2A; Tubulin beta 2A chain; Tubulin beta 2B; Tubulin beta 2B chain; Tubulin beta 2C; Tubulin beta polypeptide; Tubulin beta polypeptide 2; Tubulin beta polypeptide paralog; Tubulin beta-2 chain; Tubulin beta-2C chain; Tubulin beta-4B chain; tubulin, beta 2A class IIa; tubulin, beta 2B class IIb; tubulin, beta 4B class IVb; Tubulin, beta, class IVB; Tubulin, beta-4B
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區域：

1-445
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
基因功能參考文獻：
1. nuclear beta(II)-tubulin can modulate Notch signaling through interaction with notch1 receptor intracellular domain in cancer cells PMID: 15548702
2. The authors identified TUBB4B mutations as the cause of a previously unreported autosomal-dominant syndrome manifesting as early-onset and severe photoreceptor and cochlear cell loss. PMID: 29198720
3. The results od this study found that betaI-tubulin protein expression was decreased in the anterior cingulate cortex and increased in the dorsolateral prefrontal cortex, but not changed in superior temporal gyrus or hippocampus in schizophrenia. PMID: 22264600
4. Data suggest that increased expression of hnRNP A1, Ezrin, tubulin beta-2C and Annexin A1 in SLNMM indicate a significantly elevated early colorectal cancer metastasis. PMID: 20872967
5. Studies show that BFBTS bound and modified beta-tubulin at residue Cys12, forming beta-tubulin-SS-fluorobenzyl. PMID: 19996274
6. transformation may lead to localization of beta(II)-tubulin in cell nuclei, serving an as yet unknown function, and that nuclear beta(II) may be a useful marker for detection of tumor cells PMID: 12037579
7. Normal and tumor breast tissues, before chemotherapy or radiation treatment, have broad distributions of beta-tubulin isotypes; furthermore, beta class II tubulin predominates in most breast tissues. PMID: 12927047
8. Annexin II and beta(2)-tubulin down-regulation is important in nasopharyngeal carcinoma formation and may represent potential targets for further investigations. PMID: 18384219
顯示更多

收起更多
亞細胞定位：

Cytoplasm, cytoskeleton.
蛋白家族：

Tubulin family
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 20771

OMIM: 602660

KEGG: hsa:10383

STRING: 9606.ENSP00000341289

UniGene: Hs.433615