Recombinant Human Tropomodulin-3 (TMOD3)

中文名稱：

人TMOD3重組蛋白
貨號：

CSB-YP873694HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人TMOD3重組蛋白
貨號：

CSB-EP873694HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人TMOD3重組蛋白
貨號：

CSB-BP873694HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人TMOD3重組蛋白
貨號：

CSB-MP873694HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

TMOD3
Uniprot No.：

Q9NYL9
別名：

OTTHUMP00000162615; Tmod3; TMOD3_HUMAN; Tropomodulin 3 (ubiquitous); Tropomodulin 3 ubiquitous; Tropomodulin-3; U Tmod; U-Tmod; Ubiquitous tropomodulin; UTmod
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-352
氨基酸序列

MALPFRKDLE KYKDLDEDEL LGNLSETELK QLETVLDDLD PENALLPAGF RQKNQTSKST TGPFDREHLL SYLEKEALEH KDREDYVPYT GEKKGKIFIP KQKPVQTFTE EKVSLDPELE EALTSASDTE LCDLAAILGM HNLITNTKFC NIMGSSNGVD QEHFSNVVKG EKILPVFDEP PNPTNVEESL KRTKENDAHL VEVNLNNIKN IPIPTLKDFA KALETNTHVK CFSLAATRSN DPVATAFAEM LKVNKTLKSL NVESNFITGV GILALIDALR DNETLAELKI DNQRQQLGTA VELEMAKMLE ENTNILKFGY QFTQQGPRTR AANAITKNND LVRKRRVEGD HQ
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton.
基因功能參考文獻：
1. study has identified several new proteins like RHOC, DLG5, UGDH, TMOD3 in addition to known chemoresistance associated proteins in non-small cell lung carcinoma. PMID: 26898345
2. investigation of biomarkers for early diagnosis of endometriosis: Data suggest that TMOD3, tropomyosin 3, and stomatin-like protein 2 are autoantigens present in blood of women with endometriosis; immunodominant epitopes were identified. PMID: 22158085
3. capping of actin filament pointed ends by Tmod3 inhibits cell migration and reveal a novel control mechanism for regulation of actin filaments in lamellipodia. PMID: 12707310
4. levels of TM1, TM2 and TM3 are reduced in human transitional cell carcinoma cells, but significantly upregulated by inhibition of the mitogen-activated protein kinase-signaling pathway PMID: 15095301
5. the Tmod3 isoform may regulate actin dynamics differently in cells than the previously described tropomodulin isoforms PMID: 17012745
6. findings show that the pointed-end capping protein Tmod3 contributes to epithelial cell shape within confluent monolayers of polarized epithelial cells PMID: 17928307
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亞細胞定位：

Cytoplasm, cytoskeleton.
蛋白家族：

Tropomodulin family
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 11873

OMIM: 605112

KEGG: hsa:29766

STRING: 9606.ENSP00000308753

UniGene: Hs.4998