Recombinant Human Tripartite motif-containing protein 2 (TRIM2), partial

中文名稱：

人TRIM2重組蛋白
貨號：

CSB-YP861194HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人TRIM2重組蛋白
貨號：

CSB-EP861194HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人TRIM2重組蛋白
貨號：

CSB-EP861194HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人TRIM2重組蛋白
貨號：

CSB-BP861194HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人TRIM2重組蛋白
貨號：

CSB-MP861194HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
問答及客戶評論
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

TRIM2
Uniprot No.：

Q9C040
別名：

E3 ubiquitin protein ligase TRIM2; KIAA0517; RING finger protein 86; RNF86; Trim2; TRIM2_HUMAN; Tripartite motif containing 2; Tripartite motif protein 2; Tripartite motif protein TRIM2; Tripartite motif-containing 2; Tripartite motif-containing protein 2
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

問答及客戶評論

■ 常見問題解答

We requested info for CSB-EP861194HU (all expression systems) about a month ago. However, now we would like to know if you can provide whole polypeptide chain from residue 1 to 744, inclusive?
Best regards !

Thanks for your inquiry. As you know, we have explained that the full length of this protein has 744aa, which is very difficult to express after our comprehensive evaluation.
If you need the full length, we can provide the risk-free custom service.
Recombinant Human Tripartite motif-containing protein 2(TRIM2)
CSB-YP861194HU(A4) >> Yeast
CSB-EP861194HU(A4) >> E.coli
CSB-BP861194HU(A4) >> Baculovirus
CSB-MP861194HU(A4) >> Mammalian cell
Expression region:1-744aa; Full length.
Tag information: Tag type will be determined during the manufacturing process.
We can try to express your desired tag first if you have special request for the tag, but as we can't guarantte, if it's failed, we can provide protein with other tag.
Sequence:

MASEGTNIPSPVVRQIDKQFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMDVLQRTPGSNAEESSILETVTAVAAGKPLSCPNHDGNVMEFYCQSCETAMCRECTEGEHAEHPTVPLKDVVEQHKASLQVQLDAVNKRLPEIDSALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLLMELEVNYGLKHKVLQSQLDTLLQGQESIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNELADQDFPLHPRENDQLDFIVETEGLKKSIHNLGTILTTNAVASETVATGEGLRQTIIGQPMSVTITTKDKDGELCKTGNAYLTAELSTPDGSVADGEILDNKNGTYEFLYTVQKEGDFTLSLRLYDQHIRGSPFKLKVIRSADVSPTTEGVKRRVKSPGSGHVKQKAVKRPASMYSTGKRKENPIEDDLIFRVGTKGRNKGEFTNLQGVAASTNGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKWVSIFSSDGKFKTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSADPLYGPQGLALTSDGHVVVADSGNHCFKVYRYLQ

Reference: https://www.uniprot.org/uniprot/Q9C040
If we can successfully express this protein, you could pay the corresponding fees and we will provide the purified protein.
If we are failed in expressing this protein, you don't need to pay any fees. However you could pay for the gene synthesis and subcloning to purchase the constructed plasmid and strains if you need.
PS: The expression plasmid is not for sale if this project is successful.

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靶點詳情

功能：

UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.
基因功能參考文獻：
1. Study revealed that TRIM2 performs important functions in regulating the development and metastasis of osteosarcoma. PMID: 30066883
2. TRIM2 is associated with clinical fibrotic phenotypes of eosinophilic esophagitis. PMID: 29628359
3. We found that CREBRF and TRIM2 mRNA were significantly upregulated by rHDL, particularly in response to its phospholipid component 1-palmitoyl-2-linoleoyl-phosphatidylcholine, however, protein expression was not significantly altered. PMID: 29958463
4. TRIM2 homozygous missense mutation (c.2000A>C; p.D667A) in a patient with peripheral neuropathy and bilateral vocal cord paralysis PMID: 25893792
5. The functional role of the C-terminal NHL domain was characterized in TRIM2. PMID: 24817735
6. TRIM2 is repressed by miR-9 and -181c, either alone or in combination. PMID: 21720722
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相關疾?。?/div>
Charcot-Marie-Tooth disease 2R (CMT2R)
亞細胞定位：

Cytoplasm.
蛋白家族：

TRIM/RBCC family
數據庫鏈接：

HGNC: 15974

OMIM: 614141

KEGG: hsa:23321

STRING: 9606.ENSP00000339659

UniGene: Hs.435711