Recombinant Human Transmembrane protein 18 (TMEM18), partial

中文名稱：

人TMEM18重組蛋白
貨號：

CSB-YP023763HU1
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人TMEM18重組蛋白
貨號：

CSB-EP023763HU1
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人TMEM18重組蛋白
貨號：

CSB-EP023763HU1-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人TMEM18重組蛋白
貨號：

CSB-BP023763HU1
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人TMEM18重組蛋白
貨號：

CSB-MP023763HU1
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

TMEM18
Uniprot No.：

Q96B42
別名：

TMEM18; Transmembrane protein 18
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC).
基因功能參考文獻：
1. Significant associations were identified at 3.5 years old for TMEM18 rs6548238, NEGR1 rs2815752, BDNF rs10767664 and rs6265 (1 year old and 3.5 years old) with anthropometric phenotypes PMID: 27005443
2. Studies indicate association of transmembrane protein 18 (TMEM18) variants within the proximal haplotype block with obesity and body mass. PMID: 26365393
3. rs186019316 and rs7596758 in TMEM18 is associated with body mass index. PMID: 24951660
4. TMEM18 mRNA expression levels are related to phenotypes of obesity and glucose metabolism. PMID: 24763707
5. In summary, moderately rare missense variants within the...TMEM18 genes observed in our study did not confer risk of common childhood obesity in African Americans... PMID: 23505181
6. Results imply a regulatory role for TMEM18, BDNF, MTCH2 and NEGR1 in adipocyte differentiation and biology. In addition, we show a variation of MAF expression during adipogenesis, while NPC1, PTER and SH2B1 were not regulated. PMID: 23229156
7. TMEM18rs6548238 associated with risk of diabetes after adjustment for body mass index. PMID: 22466342
8. Meta-analysis of 4992 subjects revealed seven SNPs near four loci, including NEGR1, TMEM18, SH2B1 /ATP2A1 and MC4R, showing significant association at 0.005 PMID: 21750520
9. The polymorphisms rs6548238 and rs9935401 showed no association with educational level or income. PMID: 20628085
10. Our data suggest that SNPs in or near the TMEM18 locus contribute to obesity risk in the Greek population. PMID: 21720444
11. We observed a strong positive correlation between TMEM18 expression and body weight in the prefrontal cortex (PFC) (r = 0.5694, P = 0.0003) indicating a potential role for TMEM18 in higher functions related to feeding involving the PFC. PMID: 21952719
12. TMEM18 localises to the nuclear membrane and binds to DNA in a sequence-specific manner: perhaps this closed perinuclear localisation of TMEM18-bound DNA might repress transcription from it. PMID: 21980424
13. The risk allele TMEM18 rs6548238 was associated with bodym mass index, higher waist circumference and total body fat. PMID: 19910938
14. TMEM18 is involved in both adult and childhood obesity and found in the majority of all brain sites, including the hypothalamus and the brain stem. PMID: 20380707
15. Overexpression of TMEM18 is associated with glioma PMID: 18559506
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亞細胞定位：

Cytoplasm. Nucleus membrane; Multi-pass membrane protein.
蛋白家族：

TMEM18 family
數據庫鏈接：

HGNC: 25257

OMIM: 613220

KEGG: hsa:129787

STRING: 9606.ENSP00000281017

UniGene: Hs.43899