Recombinant Human Transient receptor potential cation channel subfamily M member 3 (TRPM3), partial

中文名稱：

人TRPM3重組蛋白
貨號：

CSB-YP884520HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人TRPM3重組蛋白
貨號：

CSB-EP884520HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人TRPM3重組蛋白
貨號：

CSB-EP884520HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人TRPM3重組蛋白
貨號：

CSB-BP884520HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人TRPM3重組蛋白
貨號：

CSB-MP884520HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

TRPM3
Uniprot No.：

Q9HCF6
別名：

TRPM3; KIAA1616; LTRPC3; Transient receptor potential cation channel subfamily M member 3; Long transient receptor potential channel 3; LTrpC-3; LTrpC3; Melastatin-2; MLSN2
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation. In addition, forms heteromultimeric ion channels with TRPM1 which are permeable for calcium and zinc ions.
基因功能參考文獻：
1. this study shows that differential expression of TRPM3 and Ca2+ flux between NK cell subtypes may provide evidence for their role in the pathomechanism involving NK cell cytotoxicity activity in chronic fatigue syndrome/myalgic encephalomyelitis PMID: 27727448
2. rs10780946 TRPM3 polymorphism is associated with asthma-exacerbated respiratory disease susceptibility. PMID: 26891941
3. Phosphoinositols regulate TRPM3. PMID: 26517445
4. Activation of TRPM3 channels increases the transcriptional activation potential of c-Fos in HEK293 cells. PMID: 26493679
5. This is the first study to examine the involvement of TRPM channel gene variations on the risk of SSc incidence. Our results suggest roles of TRPM3 and TRPM5 gene variants in the susceptibility to or clinical expression of Systemic sclerosis PMID: 26546534
6. The TRPM3 activity is rapidly and reversibly inhibited by activation of phosphatases. PMID: 26123194
7. TRPM3 is a phosphoinositide-dependent ion channel. PMID: 26123195
8. Missense mutation in the cation channel, TRPM3, underlies inherited cataract and glaucoma. PMID: 25090642
9. TRPM3 channel activation changes the gene expression pattern of the cells by activating transcription of c-Jun-, ATF2-, and TCF-controlled genes. PMID: 25576487
10. The von Hippel-Lindau tumor suppressor (VHL) represses TRPM3 directly through miR-204 and indirectly through another miR-204 target, Caveolin 1. PMID: 25517751
11. Pregnenolone sulfate is a powerful activator of TRPM3-mediated gene transcription, while transcription is completely inhibited by mefenamic acid in cells expressing activated TRPM3 channels. PMID: 24895737
12. Data using recombinant proteins expressed in vascular endothelial cells suggest that SigmaR1 (sigma 1-type opioid receptor) is not involved in regulation of calcium signaling via TRPC5/TRPM3 (transient receptor potential cation channels C5/M3). PMID: 23121507
13. TRPM3-ICF deletion mutation variants are regulatory channel subunits fine-tuning TRPM3 channel activity. PMID: 22961981
14. Progesterone (0.01-10muM) suppressed TRPM3 activity evoked by pregnenolone sulphate. PMID: 22000496
15. Calmodulin and S100A1 protein interact with N terminus of TRPM3 channel. PMID: 22451665
16. The inhibition of TRPM1 by zinc ions is primarily due to a short stretch of seven amino acids present only in the pore region of TRPM1 but not of TRPM3. PMID: 21278253
17. Our data establish that TRPM3 channels constitute a regulated entry pathway for zinc ions in pancreatic beta-cells PMID: 20401728
18. data suggest functional relevance of TRPM3 in contractile and proliferating phenotypes of vascular smooth muscle cells PMID: 20360246
19. The hTRPM3 gene is comprised of 24 exons and maps to chromosome 9q-21.12 and is composed of 1555 amino acids with the characteristic six-transmembrane domain of TRPs and is expressed in kidney and, at lesser levels, in brain, testis, and spinal cord PMID: 12672827
20. TRPM3 is the first ion channel activated by sphingolipids. PMID: 15550678
21. the divalent cation selectivity of TRPM3 channels is regulated by altenrative splicing PMID: 15824111
22. we give an overview of the identified TRPM3 variants and compare their functional properties--{REVIEW} PMID: 17217062
23. TRPM3 did not reveal a otosclerosis-causing mutation PMID: 18224337
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

Transient receptor (TC 1.A.4) family, LTrpC subfamily, TRPM3 sub-subfamily
組織特異性：

Expressed primarily in the kidney and, at lower levels, in brain, testis, ovary, pancreas and spinal cord. Expression in the brain and kidney was determined at protein level. In the kidney, expressed predominantly in the collecting tubular epithelium in t
數據庫鏈接：

HGNC: 17992

OMIM: 608961

KEGG: hsa:80036

STRING: 9606.ENSP00000366314

UniGene: Hs.47288