Recombinant Human Transcobalamin-1 (TCN1)

中文名稱：

人TCN1重組蛋白
貨號：

CSB-BP023317HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人TCN1重組蛋白
貨號：

CSB-EP023317HU-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人TCN1重組蛋白
貨號：

CSB-MP023317HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 85% as determined by SDS-PAGE.
基因名：

Name:TCN1 Synonyms:TC1
Uniprot No.：

P20061
別名：

Haptocorin; Haptocorrin; HC; OTTHUMP00000235879; TC 1; TC I; TC-1; TC1; TCI; TCN 1; TCN1; TCO1_HUMAN; Transcobalamin 1; Transcobalamin I; Transcobalamin-1; Transcobalamin1; TranscobalaminI; Vitamin B12 binding protein; Vitamin B12 binding protein R binder family
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區(qū)域：

24-433
氨基酸序列

EICEVSE ENYIRLKPLL NTMIQSNYNR GTSAVNVVLS LKLVGIQIQT LMQKMIQQIK YNVKSRLSDV SSGELALIIL ALGVCRNAEE NLIYDYHLID KLENKFQAEI ENMEAHNGTP LTNYYQLSLD VLALCLFNGN YSTAEVVNHF TPENKNYYFG SQFSVDTGAM AVLALTCVKK SLINGQIKAD EGSLKNISIY TKSLVEKILS EKKENGLIGN TFSTGEAMQA LFVSSDYYNE NDWNCQQTLN TVLTEISQGA FSNPNAAAQV LPALMGKTFL DINKDSSCVS ASGNFNISAD EPITVTPPDS QSYISVNYSV RINETYFTNV TVLNGSVFLS VMEKAQKMND TIFGFTMEER SWGPYITCIQ GLCANNNDRT YWELLSGGEP LSQGAGSYVV RNGENLEVRW SKY
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.
基因功能參考文獻：
1. Higher placental TC protein abundance was associated with higher cord blood vitamin B12 concentrations, suggesting a potential role in vitamin B12 transport to the fetus. PMID: 27577703
2. The variant rs526934 from the TCN1 gene was associated with an increased risk of developing gastric cancer. PMID: 26959381
3. Levels of holotranscobalamin are decreased patients with cobalamin deficiency. PMID: 24057896
4. Structural basis for universal corrinoid recognition by the cobalamin transport protein haptocorrin. PMID: 23846701
5. TCN1 gene expression implicates disease progression in patient with middle ear cholesteatoma. PMID: 23670528
6. comparison of human and rainbow trout cobalamin-binding protein PMID: 22872637
7. Elevated concentrations of B(12) found in autoimmune lymphoproliferative syndrome patients were due to increased lymphocyte expression of haptocorrin. PMID: 22306884
8. Stromal expression of KRT15, TCN1, and HOXB13 was significantly correlated with tumor grade, stromal hypercellularity, mitotic activity and microscopic borders. PMID: 21574054
9. two novel mutations, each causing a premature stop codon - a genetic basis for TC I deficiency PMID: 19686235
10. Comparative analysis of cobalamin binding kinetics PMID: 11788601
11. No association between the MTHFR A1298C and transcobalamin C776G genetic polymorphisms and hyperhomocysteinemia in thrombotic disease. PMID: 12590948
12. interactions of COBALAMIN BINDING proteins with a number of ligands PMID: 17487979
13. Maternal folate-related polymorphisms studied here (CBS, MTR, RFC-1, and TC) have no influence on trisomy 21 susceptibility in subjects of Brazilian population.v PMID: 19729796
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亞細胞定位：

Secreted.
蛋白家族：

Eukaryotic cobalamin transport proteins family
組織特異性：

Produced by the salivary glands of the oral cavity, in response to ingestion of food. Major constituent of secondary granules in neutrophils.
數(shù)據(jù)庫鏈接：

HGNC: 11652

OMIM: 189905

KEGG: hsa:6947

STRING: 9606.ENSP00000257264

UniGene: Hs.2012