Recombinant Human Toll-like receptor 1 (TLR1), partial

中文名稱：

人TLR1重組蛋白
貨號：

CSB-YP023599HU
說明書：

MSDS Datasheet
規(guī)格：

￥2208
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

TLR1
Uniprot No.：

Q15399
別名：

CD281; CD281 antigen; KIAA0012; LPRS5; rsc786; TIL; TIL. LPRS5; Tlr1; TLR1_HUMAN; Toll (Drosophila) homolog; Toll like receptor 1; Toll-like receptor 1; Toll/interleukin-1 receptor-like protein
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
來源：

Yeast
分子量：

65.2kDa
表達區(qū)域：

25-580aa
氨基酸序列

SEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEGLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLKALSIHQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNIDQVSSEVLEGWPDSYKCDYPESYRGTLLKDFHMSELSCNIT
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
基因功能參考文獻：
1. mean proportions of European ancestry differed significantly between the genotypes of the TLR6 (P249S) gene in a population of the Atlantic Forest, Sao Paulo, Brazil PMID: 29175392
2. rs5743618 polymorphism increased the the risk of needing inhaled corticosteroids at 11-13 years of age for postbronchiolitis asthma PMID: 28692144
3. Suggest that the TLR1 rs4833095 polymorphism may play a role in the development and progression of IgA nephropathy in a Chinese Han population. PMID: 27806314
4. genetic polymorphism is associated with transplant-related mortality in hematologic malignancies PMID: 27369862
5. Significant correlations with atherosclerosis susceptibility were found for the toll like receptor 1 (TLR1) rs5743551 polymorphism and toll like receptor 6 (TLR6) rs5743810 polymorphism. PMID: 28474755
6. Study concludes that genetic variation in the TLR10-TLR1-TLR6 gene cluster mediates responsiveness to organic dust, but indicates different signaling pathways for IL-6 and TNF-alpha. These studies provide new insight into the role of the TLR10-TLR1-TLR6 gene cluster and the innate immune response to organic dust. PMID: 28123183
7. data indicates that different TLR genes may actually play a role in the IL-17 production. In addition, different markers of TLR1, 2 and 4 appeared associated with serum levels of other important cytokines and chemokines that take part in the leprosy pathogenesis PMID: 28327786
8. Association analyses yielded a significant result for the TLR1 variant rs3923647, conferring strong protection against Tuberculosis (Odds ratio [OR] 0.21, CI confidence interval [CI] 0.05-0.6, Pnominal 1 x 10-3) when applying a recessive model of inheritance. PMID: 27214039
9. Our data suggest that TLR1 rs5743618 could serve as a predictor of clinical response to FOLFIRI plus bevacizumab in patients with mCRC. PMID: 27196764
10. rs5743551 and rs5743618 polymorphisms affected the risk of pulmonary tuberculosis in an Iranian population PMID: 27998389
11. Studied the relationship between polymorphisms in MBL, TLR1, TLR2 and TLR6 encoding genes and stimulated IFN-gamma and IL-12 ex vivo production in BCG osteitis survivors. Found that variant genotypes of the MBL2 gene (if homozygous) and variant genotypes of the TLR2 gene (only heterozygotes present) are associated with low IFN-gamma production. PMID: 27755461
12. 2 single nucleotide polymorphisms in toll like receptor 1 were significantly associated with Treponema denticola. PMID: 27727278
13. We found lower expression levels of TLR1, TLR3, TLR4, TLR7 and TLR9 in PBMCs from patients with ALL compared with those from control patients. We also observed that the PBMCs from patients with Pre-B and B ALL had lower TLR4 expression than controls PMID: 27277333
14. These data suggest that the TLR1 N248S polymorphism might play a role in Th1/Th2 differentiation, and the determination of serum IgE levels. PMID: 25825356
15. a case-control study of 504 Papua New Guinean children with severe malaria showed that a genetic variant in TLR1 may contribute to the low severe malaria case fatality rates in this region through a reduced pro-inflammatory cellular phenotype. PMID: 26633000
16. The data suggest that genetic variation in TLR1 has effects on the host response to Plasmodium falciparum malaria in Asian populations. PMID: 26738805
17. a novel mechanism of action for TLR1 SNP rs5743618 in modulating polymorphonuclear leukocytes priming responses. PMID: 26729809
18. concluded that TLR-1 rs4833095 and TLR10 rs10004195 confer susceptibility to development of gastroduodenal disease, especially GC in H.pylori disease PMID: 26559190
19. SNP TLR1-248N is associated with TB protection in an Indian population and exhibits an increased immune response to Mycobacterium tuberculosis lysate in vitro. PMID: 25857934
20. T1805G genotype associated with reduced risk of Bacillus Calmette-Guerin osteitis following infant vaccination PMID: 25605403
21. The expression of TLR1 was the lowest and expression of TLR4 was the highest on leukocytes in acute otitis media children. PMID: 24629739
22. Toll-like receptor 1 Gene SNP rs5743618 is associated with increased risk for tuberculosis in Han Chinese children. PMID: 25544311
23. TLR1 rs4833095 and TLR10 rs10004195 may play crucial roles in H. pylori susceptibility and gastric pathogenesis. PMID: 25687912
24. Data suggest that the TLR2 Arg753Gln and TLR1 Ile602Ser SNPs influence the risk of developing leptospirosis and its severity. PMID: 25784560
25. Frequencies of TLR1-TLR6 two-locus haplotypes in major populations of South Urals were determined for the first time. PMID: 26470427
26. Polymorphisms in TLR1 (R80T), NOD2 (L1007fsX1), and MYD88 (-938C>A) are associated with predisposition to development of chronic Q fever. PMID: 25722298
27. Expression of toll-like receptors 1-5 but not TLR 6-10 is elevated in livers of patients with non-alcoholic fatty liver disease. PMID: 24351080
28. rs4833095 of TLR1 may be associated with the susceptibility for alopecia areata in the Korean population PMID: 24780078
29. Genetic variation rs5743565 in TLR1 might be associated with the decreased susceptibility to Graves disease, whlie polymorphisms in TLR6 and TLR10 did not reach the statistical significance. PMID: 25028161
30. These results clarify the importance of TLR2/1 and FcgammaRII in platelet adhesion and activation, and strengthen the role of platelets as an active player in sensing bacterial infections. PMID: 25553878
31. The correlation between TLR1, TLR6, and TLR10 polymorphisms and the development of atopic dermatitis in the Republic of Bashkortostan has been found. PMID: 25850295
32. SNPs in the exons of TLR1 and TLR6 are associated with susceptibility to type 1 diabetes in the Chinese population. PMID: 25261617
33. Data show that a total of nine single-nucleotide polymorphisms (SNPs) in TLR1, TLR4, TLR6 and TLR8 in Caucasians, and two other SNPs, one each in Toll-like receptors TLR4 and TLR8, in African Americans were significantly associated with HIV status. PMID: 25253287
34. T1805G polymorphism not associated with severity of bronchiolitis or risk of postbronchiolitis wheezing PMID: 24112285
35. No association was observed for either TLR1 1805 T>G or TLR6 745 C>T polymorphism and pulmonary tuberculosis. PMID: 24984237
36. A common TLR1 polymorphism (T-->G mutation at position 1805) is associated with an increased risk of laboratory-defined neurosyphilis PMID: 24922103
37. TLR1 polymorphisms could influence immune-related disease through Teff resistance to Treg suppression. PMID: 25378593
38. This review summarizes current knowledge of the multiple roles of toll-like receptors in bacterial lung infections and highlights the mechanisms used by pathogens to modulate or interfere with TLR signaling in the lungs. PMID: 25033332
39. TLR2 and its co-receptors, TLR1 and TLR6, contribute to the pathogenicity of aPLA; aPLA are internalized via clathrin- and CD14-dependent endocytosis; and endocytosis is required for NF-kappaB activation PMID: 24612386
40. Authors demonstrated that TLR1 rs5743618 was associated with asthma and atopic eczema during the first 6 years of life after early bronchiolitis and TLR6 rs5743810 was associated with present atopy at preschool age. PMID: 24445834
41. TLR1 expression in periprosthetic tissues most accurately predicted periprosthetic joint infection. PMID: 25320195
42. the genetic architecture of TLR1 variation differs substantially in southeast Asians compared to other populations and common variation in TLR1 in Thais is not associated with outcome from melioidosis. PMID: 24392083
43. Data indicate that single nucleotide polymorphism of toll-like receptor TLR1 was significantly associated with a reduced risk of coronary artery disease (CAD). PMID: 25128583
44. Four genes showed increased expression in the epithelium of OLP patients: CD14, CXCL1, IL8, and TLR1, and at least two of these proteins, TLR1 and CXCL1, were expressed at substantial levels in oral keratinocytes. PMID: 24581860
45. Interestingly, 602Ser, which shows signatures of selection, inhibits TLR1 surface trafficking and subsequent activation of NFkappaB upon recognition of a ligand. This suggests that reduced TLR1 activity may be beneficial for human health. PMID: 24002163
46. Toll like receptor 1 single nucleotide polymorphism I602S may play a role in the pathogenesis of M. abscessus lung infection in patients with cystic fibrosis. PMID: 23403223
47. Triggering the TLR2/1 complex with Pam3CSK4 initiates human platelet activation by engaging tyrosine kinases of the src family and Syk, the adaptor protein LAT, as well as the key mediator PLCgamma2. PMID: 24240055
48. In the genetic association analysis, polymorphisms in TLR1 (S248N and R80T), TLR2 (P631H), and TLR6 (P249S) were associated with an increased susceptibility to complicated skin and skin structure infections. PMID: 24511099
49. These results suggest that TLR2/1 signaling and S1P cooperate in pro-inflammatory cytokine production and myofibroblast differentiation and promote cell migration of skin fibroblast PMID: 24440818
50. Genetic variation in TLR1 is associated with increased mortality in patients with sepsis after traumatic injury. PMID: 23478521
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Golgi apparatus.
蛋白家族：

Toll-like receptor family
組織特異性：

Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.
數(shù)據(jù)庫鏈接：

HGNC: 11847

OMIM: 601194

KEGG: hsa:7096

STRING: 9606.ENSP00000354932

UniGene: Hs.621817