Recombinant Human T-cell leukemia virus 2 Protein Tax-2 (tax)

中文名稱：

Recombinant Human T-cell leukemia virus 2 Protein Tax-2(tax)
貨號：

CSB-YP365933HQL
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human T-cell leukemia virus 2 Protein Tax-2(tax)
貨號：

CSB-EP365933HQL
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human T-cell leukemia virus 2 Protein Tax-2(tax)
貨號：

CSB-EP365933HQL-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human T-cell leukemia virus 2 Protein Tax-2(tax)
貨號：

CSB-BP365933HQL
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human T-cell leukemia virus 2 Protein Tax-2(tax)
貨號：

CSB-MP365933HQL
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

tax
Uniprot No.：

P03410
別名：

tax; Protein Tax-2; Trans-activating transcriptional regulatory protein of HTLV-2
種屬：

Human T-cell leukemia virus 2 (HTLV-2)
蛋白長度：

full length protein
表達區域：

1-331
氨基酸序列

MAHFPGFGQS LLYGYPVYVF GDCVQADWCP VSGGLCSTRL HRHALLATCP EHQLTWDPID GRVVSSPLQY LIPRLPSFPT QRTSRTLKVL TPPTTPVSPK VPPAFFQSMR KHTPYRNGCL EPTLGDQLPS LAFPEPGLRP QNIYTTWGKT VVCLYLYQLS PPMTWPLIPH VIFCHPRQLG AFLTKVPLKR LEELLYKMFL HTGTVIVLPE DDLPTTMFQP VRAPCIQTAW CTGLLPYHSI LTTPGLIWTF NDGSPMISGP YPKAGQPSLV VQSSLLIFEK FETKAFHPSY LLSHQLIQYS SFHNLHLLFD EYTNIPVSIL FNKEEADDNG D
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcriptional activator that activates both the viral long terminal repeat (LTR) and cellular promoters via activation of CREB, NF-kappa-B, SRF and AP-1 pathways. Binds to three 21 bp repeat elements located within the LTRs, referred to as Tax-responsive elements (TRE). Binding to TRE requires the interaction with CREB1 and CREBBP. Induces T-cell transformation, although much less efficiently than HTLV-1. Required for viral replication.
基因功能參考文獻：
1. A Luciferase Functional Quantitative Assay for Measuring NF-kB Promoter Transactivation Mediated by HTLV-1 and HTLV-2 Tax Proteins.( PMID: 28357663
2. the role of Tax2-mediated activation of the nuclear factor kappa B (NF-kappaB) signalling pathway on the production of the anti-viral CC-chemokines MIP-1alpha, MIP-1beta and RANTES. PMID: 24116893
3. In natural HTLV-1 infection cells expressing HTLV-1 Tax protein were significantly more frequent in clones of low abundance in vivo. PMID: 23555266
4. The authors demonstrate that a nonubiquitinable, non-SUMOylable, and nonacetylable human T cell leukemia virus type 2 tax mutant retains a significant ability to activate transcription from a NF-kappaB-dependent promoter. PMID: 23135727
5. HTLV-1 Tax1 and HTLV-2 Tax2 have many shared activities, but have a number of significantly distinct activities that appear to play key roles in HTLV-1 specific pathogenesis. We emphasize special attention to distinctions between Tax1 and Tax2. [REVIEW] PMID: 20017952
6. These results show that HTLV-2 Tax2 by itself has a growth promoting activity toward a T-cell line CTLL-2 growth of Tax2-transformed CTLL-2 cells. These results show that HTLV-2 Tax2 by itself has a growth promoting activity toward a T-cell line CTLL-2. PMID: 17140451
7. The authors demonstrate that Tax-2B is modified by ubiquitination and sumoylation. PMID: 19195675
8. Virus-specific cytotoxic T cell responses against HTLV-2 Tax protein in HTLV-2 infection are characterized for the first time. PMID: 19657093
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亞細胞定位：

Host cytoplasm. Host nucleus. Note=Tax-2 is mainly found in the cytoplasm.
蛋白家族：

Deltaretrovirus Tax protein family
數據庫鏈接：

KEGG: vg:1491946