Recombinant Human Sodium-dependent phosphate transport protein 2A (SLC34A1 NPT2 SLC17A2)

中文名稱：
貨號：

CSB-YP733714HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：
貨號：

CSB-EP733714HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：
貨號：

CSB-EP733714HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：
貨號：

CSB-BP733714HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：
貨號：

CSB-MP733714HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

NPT2A
Uniprot No.：

Q06495
別名：

Sodium-dependent phosphate transport protein 2A; Sodium-phosphate transport protein 2A; Na(+-dependent phosphate cotransporter 2A; NaPi-3; Sodium/phosphate cotransporter 2A; Na(+/Pi cotransporter 2A; NaPi-2a; Solute carrier family 34 member 1; SLC34A1 NPT2 SLC17A2
種屬：

Homo sapiens (Human)
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx.
基因功能參考文獻：
1. Our findings show that dysfunction of the human NaPiIIa causes severe renal calcification that may eventually lead to reduced kidney function, rather than complications of phosphate loss PMID: 27378183
2. Our findings expand the phenotypic spectrum of NaPi-IIa disruption, reinforce its link with proximal tubular impairment, enable longitudinal study of the natural history of the disease PMID: 29029121
3. Biallelic mutations in CYP24A1 or SLC34A1 were associated with infantile idiopathic hypercalcemia with vitamin D hypersensitivity PMID: 28470390
4. The identification of autosomal-recessive SLC34A1 mutations in infants with idiopathic infantile hypercalcemia now demonstrates a crucial role of renal sodium-phosphate cotransporter 2A for calcium metabolism as well as phosphate balance in humans PMID: 26047794
5. Estrogen downregulated NaPi-IIa only in U20S cells expressing both ERalpha and ERbeta, but not in cells expressing either receptor alone. PMID: 25608964
6. A novel homozygous mutation in the gene encoding the renal sodium-dependent phosphate transporter SLC34A1 was identified in two siblings with hypercalcemia, hypercalciuria, hypophosphatemia, low parathyroid hormone (PTH), and nephrocalcinosis. PMID: 25050900
7. B-RAF increases the cell surface protein abundance and activity of the type II Na+-coupled phosphate transporters NaPi-IIa and NaPi-IIb. PMID: 24258620
8. JAK2 contributes to the regulation of phosphate transporter NaPiIIa PMID: 23313484
9. Results indicate that the PDZ1 domain is critical for NHERF1-NPT2a interaction in humans and for the control of NPT2a expression at the plasma membrane. PMID: 22506049
10. Our cases suggest a contiguous gene deletion syndrome including NSD1 and SLC34A1 and provide a potential genetic basis for idiopathic infantile hypercalcemia. PMID: 21597970
11. Results suggest that a 31-kDa nuclear protein from kidney-derived cells binds to the C/EBP-like region of the type II Na/Pi-cotransporter promoter. PMID: 9683733
12. These findings show that disruption of the human NaPi-IIa profoundly impairs overall renal phosphate reabsorption and proximal-tubule function and provide evidence of the critical role of NaPi-IIa in human renal phosphate handling. PMID: 20335586
13. type IIc is a growth-related renal Na/P(i) cotransporter, which has a high affinity for P(i) and is electroneutral PMID: 11880379
14. mutations in the NPT2 gene may contribute to nephrocalcinosis in a subset of patients with familial hypercalciuria PMID: 12674325
15. In Xenopus oocyte expression experiments P(i)-induced currents were reduced in mutants, whereas P(i) and Na affinities and other transport characteristics were not affected PMID: 14672348
16. Taken together, these findings suggest that ECL-1 and ECL-4 may not directly form part of the transport pathway, but specific sites in these linkers can interact directly or indirectly with parts of NaPi-IIa. PMID: 15504898
17. The results allowed us to modify previous models for the transport cycle of NaPi-II transporters by including voltage dependency of HPO4(2-) binding and proton modulation of the first Na+ binding step. PMID: 15613617
18. compartmentalization may play an important role in the down-regulation of NaPi-IIa via endocytosis PMID: 16105044
19. Although genetic variants of NPT2a are not rare, they do not seem to be associated with clinically significant renal phosphate or calcium handling anomalies in a large cohort of hypercalciuric stone-forming pedigrees PMID: 16688119
20. Therefore, understanding the mechanisms that control the apical expression of NaPi-IIa and NaPi-IIc as well as their functional properties is critical to understanding how an organism achieves P i homeostasis. PMID: 16955105
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相關疾病：

Nephrolithiasis/osteoporosis, hypophosphatemic, 1 (NPHLOP1); Fanconi renotubular syndrome 2 (FRTS2); Hypercalcemia, infantile, 2 (HCINF2)
亞細胞定位：

Apical cell membrane; Multi-pass membrane protein.
蛋白家族：

SLC34A transporter family
組織特異性：

Kidney and lung.
數據庫鏈接：

HGNC: 11019

OMIM: 182309

KEGG: hsa:6569

STRING: 9606.ENSP00000321424

UniGene: Hs.936