Recombinant Human Small nuclear ribonucleoprotein E (SNRPE)

中文名稱：

人SNRPE重組蛋白
貨號：

CSB-YP022336HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人SNRPE重組蛋白
貨號：

CSB-EP022336HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人SNRPE重組蛋白
貨號：

CSB-EP022336HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人SNRPE重組蛋白
貨號：

CSB-BP022336HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人SNRPE重組蛋白
貨號：

CSB-MP022336HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

SNRPE
Uniprot No.：

P62304
別名：

AL022645; B raf; B-raf; Braf; C76690; HYPT11; RUXE_HUMAN; Sm protein E; Sm-E; Small nuclear ribonucleoprotein E; SmE; snRNP-E; snRNPE; snrpe
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區域：

1-92
氨基酸序列

MAYRGQGQKV QKVMVQPINL IFRYLQNRSR IQVWLYEQVN MRIEGCIIGF DEYMNLVLDD AEEIHSKTKS RKQLGRIMLK GDNITLLQSV SN
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
基因功能參考文獻：
1. Overexpression of SNRPE is associated with highly aggressive breast cancers. PMID: 23358685
2. Mutations in SNRPE, which encodes a core protein of the spliceosome, cause autosomal-dominant hypotrichosis simplex PMID: 23246290
3. In the SME intron, the position of the branchpoint A residue within the region base paired with U12 differs from that in P120 and XTF. PMID: 12022225
4. growth arrest by SmE directly correlates with the reduction of cyclin E, CDK2, CDC25C and CDC2 expression, and up-regulation of p27Kip PMID: 18208561
相關疾病：

Hypotrichosis 11 (HYPT11)
亞細胞定位：

Cytoplasm, cytosol. Nucleus.
蛋白家族：

SnRNP Sm proteins family
組織特異性：

Widely expressed. In scalp skin, it is present in the hair follicle, the epidermis, and the dermis.
數據庫鏈接：

HGNC: 11161

OMIM: 128260

KEGG: hsa:6635

STRING: 9606.ENSP00000400591

UniGene: Hs.334612