Recombinant Human Slit homolog 3 protein (SLIT3), partial

中文名稱：

人SLIT3重組蛋白
貨號：

CSB-YP021769HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人SLIT3重組蛋白
貨號：

CSB-EP021769HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人SLIT3重組蛋白
貨號：

CSB-BP021769HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人SLIT3重組蛋白
貨號：

CSB-MP021769HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

SLIT3
Uniprot No.：

O75094
別名：

FLJ10764; KIAA0814; MEGF 5; MEGF5; Multiple EGF-like domains protein 5; Multiple epidermal growth factor like domains 5 ; Multiple epidermal growth factor-like domains protein 5; SLIL 2; SLIL2 ; SLIT 1; Slit 2; Slit 3; Slit homolog 3 (Drosophila); Slit homolog 3; Slit homolog 3 protein; Slit-3; SLIT1; Slit2; Slit3; SLIT3_HUMAN
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.
基因功能參考文獻：
1. Overexpression of Slit3 induces its tumor suppressive effects in Breast cancer. PMID: 26542734
2. Results show that silencing of Slit3 promoted proliferation, migration and invasion of A549 cells and induced epithelial-mesenchymal transition suggesting that Slit3 functions as a tumor suppressor in lung carcinoma. PMID: 26045181
3. Estrogen-dependent expression of SLIT3 may play a key role in regulating nerve-vessel interactions within the complex microenvironment of endometriosis lesions. PMID: 25051436
4. SLIT3 is increased with labour, and both amnion and myometrial studies describe a pro-inflammatory effect of SLIT3 in these tissues. PMID: 24286238
5. High SLIT3 expression is associated with high-grade gliomas. PMID: 24158112
6. SLIT3-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo. PMID: 24090675
7. results implicate the involvement of miR-218-2 and its host gene SLIT3 in thyroid cancer cell invasion, migration, and proliferation PMID: 23720784
8. Slit3 treatment increased the in vivo homing efficiency of CD34 HSPCs to the BM in NOD/SCID mice, whereas Slit3-exposed HSPC migration in vitro was inhibited. Results support a role for Slit3 in human HSPC migration in vitro and homing in vivo. PMID: 22614124
9. SLIT3 duplication on 5q35.1 predisposes to major depressive disorder PMID: 21152026
10. The chemorepellent Slit3 promotes monocyte migration. PMID: 21078908
11. Slit3 inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis. PMID: 20298552
12. Many variants in SLIT3 tend to associate with schizophrenia susceptibility in the Chinese Han population. PMID: 15231749
13. data suggest that Slit proteins play a key role in guiding dorsally projecting cranial motoneurons and in facilitating their neural tube exit PMID: 16162649
14. In fetal and embryonic stem cell cultures Slit-3 inhibited neurite outgrowth. PMID: 16840550
15. functions to promote angiogenesis in coordinating organogenesis during embryonic development PMID: 19741192
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亞細胞定位：

Secreted.
組織特異性：

Predominantly expressed in thyroid.
數據庫鏈接：

HGNC: 11087

OMIM: 603745

KEGG: hsa:6586

STRING: 9606.ENSP00000430333

UniGene: Hs.552087