Recombinant Human Sister chromatid cohesion protein PDS5 homolog A (PDS5A), partial

中文名稱：

人PDS5A重組蛋白
貨號：

CSB-YP643713HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人PDS5A重組蛋白
貨號：

CSB-EP643713HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人PDS5A重組蛋白
貨號：

CSB-EP643713HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人PDS5A重組蛋白
貨號：

CSB-BP643713HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人PDS5A重組蛋白
貨號：

CSB-MP643713HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

PDS5A
Uniprot No.：

Q29RF7
別名：

Cell proliferation inducing protein 54 ; Cell proliferation-inducing gene 54 protein; KIAA0648; PDS5; regulator of cohesion maintenance; homolog A (S. cerevisiae); PDS5A; PDS5A_HUMAN; PIG54; SCC-112; SCC112; Sister chromatid cohesion protein 112; Sister chromatid cohesion protein PDS5 homolog A
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
基因功能參考文獻：
1. These results provide the first evidence indicating a tumor suppressor role of SA1 in early colon carcinogenesis PMID: 27549371
2. By interacting with a unique domain of Esco1, Pds5 recruits Esco1 to chromatin-bound cohesin complexes to form cohesion. PMID: 26051894
3. The data show a downregulation of proliferation-associated host gene PDS5A and suggest a role of PDS5A in HIV-1-induced cellular pathogenesis but not viral replication. PMID: 21865657
4. Data show that the siRNA-mediated knockdown of Pds5A affects sister chromatid cohesion but does not influence mitotic checkpoint function or the proliferation and survival of glioblastoma multiforme cells. PMID: 21069257
5. Findings suggest that the SCC-112 gene expression is likely to be associated with normal cell growth and proliferation. PMID: 15019998
6. SCC-112 improve cell proliferation and contributes to tumorigenesis by interacting with p63 and promoting cell cycling. PMID: 17846787
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亞細胞定位：

Nucleus.
蛋白家族：

PDS5 family
組織特異性：

Highest level in colon. Low levels in lung, ovary, breast and kidney. Reduced level in renal tumor tissue. Isoform 2 is expressed in kidney.
數據庫鏈接：

HGNC: 29088

OMIM: 613200

KEGG: hsa:23244

STRING: 9606.ENSP00000303427

UniGene: Hs.331431