Recombinant Human Short transient receptor potential channel 7 (TRPC7), partial

中文名稱：

人TRPC7重組蛋白
貨號：

CSB-YP888031HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人TRPC7重組蛋白
貨號：

CSB-EP888031HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人TRPC7重組蛋白
貨號：

CSB-EP888031HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人TRPC7重組蛋白
貨號：

CSB-BP888031HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人TRPC7重組蛋白
貨號：

CSB-MP888031HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

TRPC7
Uniprot No.：

Q9HCX4
別名：

Capacitative calcium channel TRPC7 ; cation channel; subfamily C; member 7; hTRP7; KNP3 ; Likley ortholog of mouse transient receptor potential cation channel subfamily C member 7; mTRP7; Putative capacitative calcium channel; Short transient receptor potential channel 7; Transient receptor potential cation channel subfamily C member 7; transient receptor potential-related channel 7; a novel putative Ca2+ channel protein ; Transient receptor protein 7; TRP 7; TRP-7; TRP7 protein; TRPC 7; TrpC7; Trpc7 transient receptor potential cation channel; subfamily C; member 7; TRPC7_HUMAN; TRPM2 ; Trrp8
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG). May also be activated by intracellular calcium store depletion.
基因功能參考文獻：
1. A fundamental role for PI(4,5)P2 was identified in the regulation of TRPC7 and TRPC6. PMID: 24470487
2. Phosphorylation of transient receptor potential cation channel subfamily C member 7 significantly suppressed carbachol-induced calcium influx and CREB phosphorylation. PMID: 21402151
3. Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx PMID: 11805119
4. can be activated by both receptor- and store-operated modes in the same cell. PMID: 15342342
5. endogenous TRPC1, TRPC3, and TRPC7 participate in forming heteromeric store-operated channels, whereas TRPC3 and TRPC7 can also participate in forming heteromeric receptor-operated channels. PMID: 15972814
6. in B-lymphocytes, TRPC7 appears to participate in the formation of ion channels that could be activated by phospholipase C-linked receptors PMID: 16123040
7. activation of both muscarinic and purinergic receptors via a common DAG-dependent link opens Ca(2+)-permeable TRPC7 channels PMID: 16741513
8. the physiological importance of TRPC7 in the native environment remains elusive, TRPC7 would play important roles in Ca2+ signaling pathway--{REVIEW} PMID: 17217055
9. Expression and activity of TRPM7 is modulated by extracellular Mg2+ and Ca2+ availability, indicating that TRPM7 channels are involved in intracellular ion homeostasis and proliferation of osteoblasts. PMID: 18021175
10. heteromeric cation channels comprised of the TRPP2 mutant and the TRPC3 or TRPC7 protein induce enhanced receptor-activated Ca(2+) influx that may lead to dysregulated cell growth in ADPKD PMID: 19812035
顯示更多

收起更多
亞細胞定位：

Cell membrane; Multi-pass membrane protein. Nucleus envelope.
蛋白家族：

Transient receptor (TC 1.A.4) family, STrpC subfamily, TRPC7 sub-subfamily
數據庫鏈接：

HGNC: 20754

KEGG: hsa:57113

STRING: 9606.ENSP00000426070

UniGene: Hs.591263