Recombinant Human Short stature homeobox protein 2 (SHOX2)

中文名稱：

人SHOX2重組蛋白
貨號(hào)：

CSB-YP021277HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人SHOX2重組蛋白
貨號(hào)：

CSB-EP021277HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人SHOX2重組蛋白
貨號(hào)：

CSB-EP021277HU-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人SHOX2重組蛋白
貨號(hào)：

CSB-BP021277HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人SHOX2重組蛋白
貨號(hào)：

CSB-MP021277HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

SHOX2
Uniprot No.：

O60902
別名：

Homeobox protein Og12X; OG 12; OG 12X; OG12; OG12X; OGI 2X; OGI2X; Paired related homeobox protein SHOT; Paired-related homeobox protein SHOT; Short stature homeobox 2; Short stature homeobox homolog; Short stature homeobox protein 2; SHOT; SHOX 2; SHOX homologous gene on chromosome 3; SHOX2; SHOX2_HUMAN
種屬：

Homo sapiens (Human)
蛋白長(zhǎng)度：

Full length protein
表達(dá)區(qū)域：

1-331
氨基酸序列

MEELTAFVSK SFDQKVKEKK EAITYREVLE SGPLRGAKEP TGCTEAGRDD RSSPAVRAAG GGGGGGGGGG GGGGGGGVGG GGAGGGAGGG RSPVRELDMG AAERSREPGS PRLTEVSPEL KDRKEDAKGM EDEGQTKIKQ RRSRTNFTLE QLNELERLFD ETHYPDAFMR EELSQRLGLS EARVQVWFQN RRAKCRKQEN QLHKGVLIGA ASQFEACRVA PYVNVGALRM PFQQDSHCNV TPLSFQVQAQ LQLDSAVAHA HHHLHPHLAA HAPYMMFPAP PFGLPLATLA ADSASAASVV AAAAAAKTTS KNSSIADLRL KAKKHAAALG L
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation.
基因功能參考文獻(xiàn)：
1. the methylation positive rates of SHOX2 with RASSF1A in stage III were both higher than the other stages of lung cancer PMID: 28325362
2. High SHOX2 methylation is associated with Lung cancer. PMID: 27544059
3. important role in the process of intervertebral disc degeneration PMID: 26697824
4. Data suggest that the microRNA miR-375/short stature homeobox 2 protein (SHOX2) axis may be a novel therapeutic target for esophageal squamous cell carcinoma (ESCC). PMID: 28069583
5. Study showed that SHOX2 methylation levels in adenomas and colorectal carcinomas (CRC) were significantly higher compared to those in normal control tissues. Histologic transition from adenomas to CRC was paralleled by amplification of the SEPT9 gene locus. PMID: 27660666
6. Study found SHOX2 and SEPT9 frequently methylated in biliary tract cancers. PMID: 27999621
7. We have identified that SHOX2 expression or methylation are potent independent prognostic indicators for predicting LGG patient survival, and have potential to identify an important subset of LGG patients with IDHwt status with significantly better overall survival. PMID: 27840009
8. Whole-genome microarray mRNA-expression profiles of myofibroblasts and skin fibroblasts revealed four additional genes that are significantly differentially expressed in these two cell types: NKX2-3 and LRRC17 in myofibroblasts and SHOX2 and TBX5 in skin fibroblasts PMID: 27036009
9. these results suggest a genetic contribution of SHOX2 in early-onset atrial fibrillation PMID: 27138930
10. The longitudinal measurement of extracellular plasma mSHOX2 DNA yields information about the response to cytotoxic treatment and allows an early assessment of treatment response for lung cancer patients. PMID: 25675432
11. SHOX2 overexpression favors differentiation of embryonic stem cells into cardiac pacemaker cells, improving biological pacing ability. PMID: 25533636
12. SHOX2 DNA methylation identified 66% of the patients with cancer subsequent to a cytological equivocal diagnosis. SHOX2 complements the cytological diagnosis and the methylation marker panel. PMID: 25331797
13. miR-375/SHOX2 functional relationship regulates breast tumorigenesis by controlling the process of EMT. PMID: 24746361
14. SHOX2, like SHOX, regulates NPPB directly whilst activates ACAN via its cooperation with the SOX trio. PMID: 24421874
15. prognostic value of SHOX2 and SEPT9 DNA methylation in benign, paramalignant and malignant pleural effusions PMID: 24386354
16. Elevated SHOX2 expression is associated with tumor recurrence of hepatocellular carcinoma. PMID: 23851611
17. The combination of EBUS-TBNA and SHOX2 methylation level strongly improves the assessment of the nodal status by identifying additional malignant lesions and confirming benign nodes and therefore avoiding invasive follow-up procedures. PMID: 24026539
18. The assay is based on quantification of methylated Short Stature Homeobox gene two (SHOX2) DNA in the specimen measured via multiplex real-time Polymerase Chain Reaction (PCR) on bisulfite-converted DNA. PMID: 24136974
19. Shox2 regulates progression through chondrogenesis at two distinct stages--the onset of early differentiation and the transition to maturation and hypertrophy. PMID: 23038774
20. DNA methylation of PITX2 and SHOX2 is an independent prognostic biomarker for disease progression in non-small-cell lung cancer patients. PMID: 22555092
21. A CE marked in vitro diagnostic test kit to quantify SHOX2 DNA methylation in bronchial aspirates was developed and characterized. PMID: 22108652
22. SHOX2 DNA methylation is associated with lung cancer. PMID: 21694641
23. Frequent gene amplification correlated with hypermethylation of the SHOX2 gene locus. PMID: 21426551
24. work establishes a link between Tbx5, Shox2 and Bmp4 in the pacemaker region of the developing heart PMID: 20858598
25. SHOX2 DNA methylation is found in bronchial aspirates of lung cancer patients PMID: 21047392
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亞細(xì)胞定位：

Nucleus.
蛋白家族：

Paired homeobox family, Bicoid subfamily
組織特異性：

Expressed in heart, skeletal muscle, liver, lung, bone marrow fibroblast, pancreas and placenta.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 10854

OMIM: 602504

KEGG: hsa:6474

STRING: 9606.ENSP00000419362

UniGene: Hs.55967