Recombinant Human Rho GTPase-activating protein 22 (ARHGAP22)

中文名稱：

Recombinant Human Rho GTPase-activating protein 22(ARHGAP22)
貨號：

CSB-YP773596HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Rho GTPase-activating protein 22(ARHGAP22)
貨號：

CSB-EP773596HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Rho GTPase-activating protein 22(ARHGAP22)
貨號：

CSB-EP773596HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Rho GTPase-activating protein 22(ARHGAP22)
貨號：

CSB-BP773596HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Rho GTPase-activating protein 22(ARHGAP22)
貨號：

CSB-MP773596HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ARHGAP22
Uniprot No.：

Q7Z5H3
別名：

ARHGAP22; RHG22_HUMAN; Rho GTPase activating protein 2; Rho GTPase activating protein 22; Rho GTPase-activating protein 22; Rho type GTPase activating protein 22; Rho-type GTPase-activating protein 22; RhoGAP2; RhoGap22
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-698
氨基酸序列

MLSPKIRQAR RARSKSLVMG EQSRSPGRMP CPHRLGPVLK AGWLKKQRSI MKNWQQRWFV LRGDQLFYYK DKDEIKPQGF ISLQGTQVTE LPPGPEDPGK HLFEISPGGA GEREKVPANP EALLLMASSQ RDMEDWVQAI RRVIWAPLGG GIFGQRLEET VHHERKYGPR LAPLLVEQCV DFIRERGLTE EGLFRMPGQA NLVRDLQDSF DCGEKPLFDS TTDVHTVASL LKLYLRELPE PVVPFARYED FLSCAQLLTK DEGEGTLELA KQVSNLPQAN YNLLRYICKF LDEVQAYSNV NKMSVQNLAT VFGPNILRPQ VEDPVTIMEG TSLVQHLMTV LIRKHSQLFT APVPEGPTSP RGGLQCAVGW GSEEVTRDSQ GEPGGPGLPA HRTSSLDGAA VAVLSRTAPT GPGSRCSPGK KVQTLPSWKS SFRQPRSLSG SPKGGGSSLE VPIISSGGNW LMNGLSSLRG HRRASSGDRL KDSGSVQRLS TYDNVPAPGL VPGIPSVASM AWSGASSSES SVGGSLSSCT ACRASDSSAR SSLHTDWALE PSPLPSSSED PKSLDLDHSM DEAGAGASNS EPSEPDSPTR EHARRSEALQ GLVTELRAEL CRQRTEYERS VKRIEEGSAD LRKRMSRLEE ELDQEKKKYI MLEIKLRNSE RAREDAERRN QLLQREMEEF FSTLGSLTVG AKGARAPK
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter.
基因功能參考文獻：
1. There is a significant association between single nucleotide polymorphism in the ARHGAP22 gene and diabetic retinopathy risk in a Han Chinese population PMID: 28544509
2. a weak complex between RhoGAP protein ARHGAP22 and signal regulatory protein 14-3-3 has 1:2 stoichiometry and a single peptide binding mode PMID: 22952583
3. The interaction of the IL1RAPL1 family of proteins with PTPdelta and RhoGAP2 reveals a pathophysiological mechanism of cognitive impairment associated with a novel type of trans-synaptic signaling. PMID: 21926414
4. Identification of RhoGAP22 as an Akt-dependent regulator of cell motility in response to insulin PMID: 21969604
5. We identified a genetic association for susceptibility to retinopathy in 5 novel chromosomal regions and PLXDC2 and ARHGAP22, the latter 2 of which are genes implicated in endothelial cell angiogenesis and increased capillary permeability. PMID: 21310492
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亞細胞定位：

Cytoplasm. Nucleus.
數據庫鏈接：

HGNC: 30320

OMIM: 610585

KEGG: hsa:58504

STRING: 9606.ENSP00000249601

UniGene: Hs.655672