Recombinant Human Regulator of G-protein signaling 8 (RGS8)

中文名稱：

人RGS8重組蛋白
貨號：

CSB-YP019661HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人RGS8重組蛋白
貨號：

CSB-EP019661HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人RGS8重組蛋白
貨號：

CSB-EP019661HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人RGS8重組蛋白
貨號：

CSB-BP019661HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人RGS8重組蛋白
貨號：

CSB-MP019661HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

RGS8
Uniprot No.：

P57771
別名：

Regulator of G Protein Signalling 8; Regulator of G-protein signaling 8; RGS8; RGS8_HUMAN
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區域：

1-180
氨基酸序列

MAALLMPRRN KGMRTRLGCL SHKSDSCSDF TAILPDKPNR ALKRLSTEEA TRWADSFDVL LSHKYGVAAF RAFLKTEFSE ENLEFWLACE EFKKTRSTAK LVSKAHRIFE EFVDVQAPRE VNIDFQTREA TRKNLQEPSL TCFDQAQGKV HSLMEKDSYP RFLRSKMYLD LLSQSQRRLS
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling.
基因功能參考文獻：
1. The chimeric RGS8 domains containing the first or the second exon part of RGS5 showed strong inhibitory effects similar to that of wild type RGS8, but the chimeric domain with the third exon part of RGS5 lost its activity PMID: 26754208
2. Missense mutations in RGS8 gene is associated with breast cancer. PMID: 21135262
3. Spinophilin was identified as an RGS8-interacting protein. PMID: 18834863
亞細胞定位：

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane; Peripheral membrane protein; Cytoplasmic side. Perikaryon. Cell projection, dendrite. Nucleus.
數據庫鏈接：

HGNC: 16810

OMIM: 607189

KEGG: hsa:85397

STRING: 9606.ENSP00000258302

UniGene: Hs.20982