Recombinant Human Regulator of G-protein signaling 12 (RGS12), partial

中文名稱：

人RGS12重組蛋白
貨號：

CSB-YP019644HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人RGS12重組蛋白
貨號：

CSB-EP019644HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人RGS12重組蛋白
貨號：

CSB-EP019644HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人RGS12重組蛋白
貨號：

CSB-BP019644HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人RGS12重組蛋白
貨號：

CSB-MP019644HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

RGS12
Uniprot No.：

O14924
別名：

RGS12; Regulator of G-protein signaling 12; RGS12
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form.; Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis.
基因功能參考文獻：
1. Findings identify RGS12 as a candidate tumor-suppressor gene in AA prostate cancer, which acts by decreasing expression of AKT and MNX1, establishing a novel oncogenic axis in this disparate disease setting. PMID: 28611045
2. Data support the notion that the Galpha, but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 activation and unveil new roles for RGS and RGS12 in fine-tuning TRPC4 activities. PMID: 26987813
3. RGS12 is essential for the terminal differentiation of osteoclasts induced by RANKL. PMID: 17042716
4. shows chromosomal mapping information for human locus. PMID: 9168931
亞細胞定位：

Nucleus. Cytoplasm. Cell projection, dendrite. Cell junction, synapse.; [Isoform 5]: Nucleus matrix.
組織特異性：

Isoform 3 is brain specific.
數據庫鏈接：

HGNC: 9994

OMIM: 602512

KEGG: hsa:6002

STRING: 9606.ENSP00000339381

UniGene: Hs.527061