Recombinant Human Protein-cysteine N-palmitoyltransferase HHAT (HHAT), partial

中文名稱：

人HHAT重組蛋白
貨號：

CSB-YP719621HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人HHAT重組蛋白
貨號：

CSB-EP719621HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人HHAT重組蛋白
貨號：

CSB-EP719621HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人HHAT重組蛋白
貨號：

CSB-BP719621HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人HHAT重組蛋白
貨號：

CSB-MP719621HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

HHAT
Uniprot No.：

Q5VTY9
別名：

2810432O22Rik; AC115917.1; AI462858; FLJ10724; FLJ34867; Hedgehog acyltransferase; Hhat; HHAT_HUMAN; MART 2; MART-2; MART2; Melanoma antigen recognized by T cells 2; Melanoma antigen recognized by T-cells 2; MGC11697; OTTMUSP00000033669; Protein cysteine N palmitoyltransferase HHAT; Protein-cysteine N-palmitoyltransferase HHAT; RGD1311746; SKI1; Skinny hedgehog protein 1; Skinny hedgehog protein; Skn
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Palmitoyl acyltransferase that catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling. Promotes the transfer of palmitoyl-CoA from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane, where SHH palmitoylation occurs.
基因功能參考文獻：
1. Hhat plays a critical role in ER positive, HER2 amplified, and hormone resistant breast cancer proliferation. PMID: 25889650
2. Data suggest that substrate specificity of hedgehog acyltransferase (HHAT) in palmitoylation reaction extends to oligopeptide fragments of Sonic hedgehog protein (SHH). PMID: 26334609
3. analysis of hedgehog acyltransferase membrane topology PMID: 25488661
4. provide the first clinical evidence of the essential role played by lipid modification of Hh proteins in human testicular organogenesis and embryonic development PMID: 24784881
5. rs7527939 is the strongest indicator of susceptibility to schizophrenia in the Bulgarian population within the HHAT locus. PMID: 23142968
6. SKN is necessary for the proliferation of the non-small cell lung carcinoma cells PMID: 22733134
7. These findings define residues and regions within Shh that are necessary for its recognition as a substrate for Hhat-mediated palmitoylation. PMID: 23112049
8. SKI-1/S1P activity is thus essential for hepatitis C virus production and its inhibition should be considered for antiviral drug development. PMID: 22626636
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亞細胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
蛋白家族：

Membrane-bound acyltransferase family, HHAT subfamily
組織特異性：

Ubiquitously expressed in normal tissues and cancer cell lines.
數據庫鏈接：

HGNC: 18270

OMIM: 605743

KEGG: hsa:55733

STRING: 9606.ENSP00000438468

UniGene: Hs.58650