Recombinant Human Protein RIC-3 (RIC3), partial

中文名稱：

人RIC3重組蛋白
貨號(hào)：

CSB-YP800217HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人RIC3重組蛋白
貨號(hào)：

CSB-EP800217HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人RIC3重組蛋白
貨號(hào)：

CSB-EP800217HU-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人RIC3重組蛋白
貨號(hào)：

CSB-BP800217HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人RIC3重組蛋白
貨號(hào)：

CSB-MP800217HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

RIC3
Uniprot No.：

Q7Z5B4
別名：

AYST720; FLJ11608; PRO1385; Protein RIC-3; Resistance to inhibitors of cholinesterase 3 homolog; Resistant to inhibitor of cholinesterase 3; RIC3 acetylcholine receptor chaperone; Ric3; RIC3_HUMAN
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Molecular chaperone which facilitates proper subunit assembly and surface trafficking of alpha-7 (CHRNA7) and alpha-8 (CHRNA8) nicotinic acetylcholine receptors. May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4.
基因功能參考文獻(xiàn)：
1. Two RIC3 gene haplotypes of four variants: A-G-C-G, and C-A-C-A might relate to either protection against or increased susceptibility to PD in the Han Chinese population, respectively. PMID: 28606768
2. RIC3 mutations are not a common cause of PD in the French-Canadian and French populations. PMID: 28153381
3. RIC3 is a known chaperone of neuronal nicotinic acetylcholine receptor subunit alpha-7 (CHRNA7). PMID: 27055476
4. 5-HT3A-ICD is not only required but also sufficient for interaction with RIC-3 PMID: 27045630
5. expression of chaperones such as Ric-3 can influence proteins associating with alpha7-nAChRs PMID: 26258666
6. RIC-3 differentially regulates assembly and expression of different nicotinic receptor subunits. These results also show that nicotine-mediated upregulation of alpha4beta2 receptors can be dynamically regulated by the presence of the chaperone, RIC-3. PMID: 23586521
7. RIC-3 gene rs1528133 variation was not found to be effective over any analyzed obesity related parameter, but associated with higher glycemic load, protein and fat eating behavior and antihypertensive drug use PMID: 23153976
8. Xenopus laevis RIC-3 is more effective than either the homomeric human or C. elegans protein in chaperoning the expression of nematode nicotinic receptor ACR-16 in Xenopus oocytes. PMID: 22970690
9. RIC-3 exclusively enhances the surface expression of human homomeric 5-hydroxytryptamine type 3A (5-HT3A) receptors despite direct interactions with 5-HT3A, -C, -D, and -E subunits. PMID: 20522555
10. the hric3 locus encodes for multiple transcripts, is likely to produce multiple hric3 isoforms, and hric3 is expressed in neurons and muscles, thus enabling its interactions with nicotinic acetylcholine receptors in vivo PMID: 12821669
11. ric-3 appears to be necessary for proper folding and/or assembly of alpha7 receptors in HEK293 cells PMID: 15504725
12. RIC-3 may play a role in 5-HT(3A) receptor folding, assembly, or transport to the cell surface PMID: 15809299
13. hRIC-3 can act as a specific regulator of alpha7 and 5-HT3 expression at different levels by increasing the number of mature receptors and facilitating its transport to the membrane PMID: 15927954
14. Mutations in the ric-3 gene affect maturation of nicotinic acetylcholine receptors. PMID: 17192664
15. both isoforms of RIC-3 play a role in determining 5-HT3 receptor composition. PMID: 17609200
16. Immunohistochemistry demonstrated the presence of RIC-3 in rat brain localized, in general, in places where alpha7 nAChRs were found. PMID: 18179477
17. When expressed in a human cell line, human RIC-3 enhances neuronal nicotinic acetylcholine receptor maturation more efficiently than Drosophila melanogaster RIC-3. PMID: 18208544
18. this review provides a brief history of RIC-3--REVIEW PMID: 18246096
19. we describe the generation and functional and pharmacological characterization of a Chinese hamster ovary (CHO)-K1 cell line co-expressing the human alpha7 nAChR and RIC-3 PMID: 18471073
20. The RIC-3e protein is functionally active and enables surface expression of mature alpha7-nAChRs in cell lines not otherwise permissive for the expression of this receptor. PMID: 18691158
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亞細(xì)胞定位：

[Isoform 1]: Endoplasmic reticulum membrane; Single-pass membrane protein.; [Isoform 2]: Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
蛋白家族：

Ric-3 family
組織特異性：

Broadly expressed, with high levels in muscle, brain, heart, pancreas and testis. In the central nervous system, highest levels are detected in the cerebellum and pituitary gland. Over-expressed in brains from patients with bipolar disease or schizophreni
數(shù)據(jù)庫鏈接：

HGNC: 30338

OMIM: 610509

KEGG: hsa:79608

STRING: 9606.ENSP00000308820

UniGene: Hs.231850