Recombinant Human PDZ and LIM domain protein 3 (PDLIM3)

中文名稱：

人PDLIM3重組蛋白
貨號：

CSB-YP690477HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人PDLIM3重組蛋白
貨號：

CSB-EP690477HU-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人PDLIM3重組蛋白
貨號：

CSB-BP690477HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人PDLIM3重組蛋白
貨號：

CSB-MP690477HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

PDLIM3
Uniprot No.：

Q53GG5
別名：

Actinin associated LIM protein; Actinin-associated LIM protein; Alpha actinin 2 associated LIM protein; Alpha-actinin-2-associated LIM protein; DKFZp686L0362; Enigma homolog; PDLI3_HUMAN; PDLIM 3; PDLIM3; PDZ and LIM domain 3; PDZ and LIM domain protein 3
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-364
氨基酸序列

MPQTVILPGP APWGFRLSGG IDFNQPLVIT RITPGSKAAA ANLCPGDVIL AIDGFGTESM THADAQDRIK AAAHQLCLKI DRGETHLWSP QVSEDGKAHP FKINLESEPQ DGNYFEHKHN IRPKPFVIPG RSSGCSTPSG IDCGSGRSTP SSVSTVSTIC PGDLKVAAKL APNIPLEMEL PGVKIVHAQF NTPMQLYSDD NIMETLQGQV STALGETPLM SEPTASVPPE SDVYRMLHDN RNEPTQPRQS GSFRVLQGMV DDGSDDRPAG TRSVRAPVTK VHGGSGGAQR MPLCDKCGSG IVGAVVKARD KYRHPECFVC ADCNLNLKQK GYFFIEGELY CETHARARTK PPEGYDTVTL YPKA
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

May play a role in the organization of actin filament arrays within muscle cells.
基因功能參考文獻(xiàn)：
1. This study confirmed that PDLIM3 as genetic modifiers of age at onset of Alzheimer disease. PMID: 26214276
2. two abnormal splicing events for actinin-associated LIM protein 3 (PDLIM3/ALP) and fibronectin 1 (FN1) in the skeletal muscles of myotonic dystrophy type 1 patients. PMID: 21549096
3. mutations in PDLIM3 and MYPN are infrequent in hypertrophic cardiomyopathies PMID: 20801532
4. ZASP-like motif in actinin-associated LIM protein is required for interaction with the alpha-actinin rod and for targeting to the muscle Z-line PMID: 15084604
5. Mutations in PDLIM3 and MYOZ1, encoding myocyte Z line proteins, do not play any significant role in the genetic etiology of idiopathic DCM. PMID: 17254821
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亞細(xì)胞定位：

Cytoplasm, myofibril, sarcomere, Z line. Note=Localizes to myofiber Z-lines.
組織特異性：

Isoform 1 is highly expressed in differentiated skeletal muscle. Isoform 2 is heart-specific.
數(shù)據(jù)庫鏈接：

HGNC: 20767

OMIM: 605889

KEGG: hsa:27295

STRING: 9606.ENSP00000284770

UniGene: Hs.701364