Recombinant Human Neuropeptide Y receptor type 2 (NPY2R), partial
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中文名稱：人NPY2R重組蛋白
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貨號：CSB-EP016036HU1-B
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說明書：
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規(guī)格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產(chǎn)品詳情
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純度：>85% (SDS-PAGE)
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基因名：
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Uniprot No.：
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別名：NPY2R; Neuropeptide Y receptor type 2; NPY2-R; NPY-Y2 receptor; Y2 receptor
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種屬：Homo sapiens (Human)
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蛋白長度：partial, the last Cytoplasmic domain
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蛋白標(biāo)簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產(chǎn)品提供形式：Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復(fù)溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲(chǔ)存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質(zhì)期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項(xiàng)：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.
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基因功能參考文獻(xiàn)：
- The present study explored whether functional NPY2R variant rs6857715 (C-599T) showed an association with Major Depressive Disorder. Analysis of the overall sample (595 MDD cases; 1295 controls) showed an association with the AD risk allele C. The present findings suggest that the NPY2R rs6857715 C-allele makes a genuine contribution toward MDD PMID: 27584037
- not detected in infantile hemanogiomas PMID: 27889920
- polymorphisms in the NPY2R gene may be useful in identifying women at risk for osteoporosis. PMID: 25871004
- Data show that the Y2-receptor high expression G allele is associated with a less efficient mode of action cascading where different task goals are activated in parallel. PMID: 25157429
- The molecular mobility of the human neuropeptide Y receptor type 2 reconstituted into dimyristoylphosphatidylcholine (DMPC) membranes was investigated by means of solid-state NMR spectroscopy. PMID: 24623336
- The results of this study provide evidence that the functionally relevant single nucleotide polymorphism (SNP) in the NPY2R promoter gene affect circumscribed processes of early sensory processing PMID: 24709141
- This study reviews neuropeptide Y2 receptor modulators (mainly non-peptidic antagonists) and their structure-activity relationships. PMID: 24365162
- this study concludes that common genetic variation in the proximal NPY2R promoter influences transcription factor binding so as to alter gene expression in neuroendocrine cells, and consequently cardiometabolic traits in humans. PMID: 23149563
- we determined the role of the C-terminus in the anterograde transport of the human neuropeptide Y receptor (hYR) type 2 PMID: 23020974
- Surface masking of the Y2 receptor could to a degree reflect restricted access of the large (34-36-residue) physiological agonists. PMID: 22732667
- NPY2R expression in neonatal saliva is predictive of an immature feeding pattern. PMID: 22629465
- Four genetic loci were strongly and independently associated with obesity, NPY2R, NPFFR2, MC4R, and FTO. PMID: 21818152
- protocol for the preparation of fully active Y2 G protein-coupled receptor PMID: 21999704
- Data present a site-directed mutagenesis study of four amino acid positions in the human Y2 receptor. PMID: 21696823
- Results report on the functional reconstitution of the hY(2)R and the hY(4)R in Sf9 insect cells using the baculovirus system. PMID: 21745157
- Increased expression of NPY-Y2 receptors in symptomatic carotid plaque vascular smooth muscle cells. PMID: 21352822
- These results suggest that the rs4425326 polymorphism in NPY2R may be a possible genetic factor for nicotine dependence in the Japanese elderly population. PMID: 20811389
- Ligand-induced internalization and recycling of the human neuropeptide Y2 receptor is regulated by its carboxyl-terminal tail PMID: 20959467
- effect on metabolic parameters of single nucleotide polymorphisms in the 5'-flanking region of NPY2R gene PMID: 20359722
- NPY receptor Y2 polymorphism is independently associated with left ventricular mass index and interacts with plasma levels of NPY in explaining the variability of left ventricular hypertrophy in ESRD. PMID: 20543711
- Described is the membrane reconstitution of the refolded human neuropeptide Y receptor Type 2 (Y2 receptor) into phospholipid membranes. PMID: 20421142
- Several LEP, and NPY2R and PYY SNPs were associated with obesity-related phenotypes in young adults, particularly among African-Americans. PMID: 20642810
- Mutation rate of the rs1047214 polymorphism in NPY2R gene in Chinese adolescents was higher than in foreign populations. Polymorphism seemed to be associated with obesity in males but did not in phenotypes of metabolic syndrome. PMID: 19957593
- Report binding and pharmacology of neuropeptide Y Y2 receptor antagonist JNJ-31020028. PMID: 19953226
- Peptide YY and neuropeptide Y exert their effects through the NPY2 receptors, which are located on intrinsic neurons as well as epithelia in colon mucosa. PMID: 11906964
- tonic activation of submucosal Y(2) receptors could indirectly reduce mucosal ion transport in the colon, while direct activation of Y(2) receptors on longitudinal muscle results in contraction PMID: 12813010
- mutations in PYY and Y2R are not commonly found in humans with severe early-onset obesity. PMID: 15331560
- High expression of neuropeptide Y receptor Y2 is associated with tumors of the human adrenal gland and extra-adrenal paraganglia PMID: 15623622
- Y2R pathway may influence body weight through a sex-specific mechanism. PMID: 15855352
- Neuropeptide-Y induced endothelial cell migration was mimicked by agonists and fully blocked by antagonists for any specific NPY receptor (NPY2R). PMID: 16891622
- Common variants in the 5' region of NPY2R are associated with obesity in Danish white subjects. PMID: 17019604
- A rare variant of the NPY2R gene showed evidence of co-segregation with obesity. PMID: 17235527
- NPY2R should be considered a candidate gene for type 2 diabetes in men. PMID: 17325259
- In case-control analyses and a family-based association study an association with obesity for seven common variants was not detected; additional gender-stratified analyses were also nonsignificant. PMID: 17992642
- The rabbit kidney and the human CHO cell-expressed Y2 dimers are converted by agonists to monomers in vitro at a similar rate in the presence of divalent cations. PMID: 18569526
- Y2R gene variants are involved in blood pressure regulation in obese children and adolescents PMID: 18622237
- the N-terminal extracellular segment of the neuropeptide Y Y2 receptor thus apparently has a large role in anchoring and compartmentalization of the receptor PMID: 18700141
- Single nucleotide polymorphisms in NPY2R provide significant evidence of association with alcohol dependence, alcohol withdrawal symptoms, comorbid alcohol and cocaine dependence, and cocaine dependence. PMID: 18828811
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亞細(xì)胞定位：Cell membrane; Multi-pass membrane protein.
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蛋白家族：G-protein coupled receptor 1 family
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組織特異性：High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra.
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