Recombinant Human Neuronal pentraxin-2 (NPTX2)

中文名稱：

人NPTX2重組蛋白
貨號：

CSB-YP016030HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人NPTX2重組蛋白
貨號：

CSB-EP016030HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人NPTX2重組蛋白
貨號：

CSB-EP016030HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人NPTX2重組蛋白
貨號：

CSB-BP016030HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人NPTX2重組蛋白
貨號：

CSB-MP016030HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

NPTX2
Uniprot No.：

P47972
別名：

apexin; NARP; neuronal activity-regulated pentaxin; Neuronal pentraxin 2; Neuronal pentraxin II; Neuronal pentraxin-2; NP 2; NP-II; NP2; NPII ; NPTX2; NPTX2_HUMAN; pentraxin II, neuronal
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區域：

16-431
氨基酸序列

GAQDS PAPGSRFVCT ALPPEAVHAG CPLPAMPMQG GAQSPEEELR AAVLQLRETV VQQKETLGAQ REAIRELTGK LARCEGLAGG KARGAGATGK DTMGDLPRDP GHVVEQLSRS LQTLKDRLES LEHQLRANVS NAGLPGDFRE VLQQRLGELE RQLLRKVAEL EDEKSLLHNE TSAHRQKTES TLNALLQRVT ELERGNSAFK SPDAFKVSLP LRTNYLYGKI KKTLPELYAF TICLWLRSSA SPGIGTPFSY AVPGQANEIV LIEWGNNPIE LLINDKVAQL PLFVSDGKWH HICVTWTTRD GMWEAFQDGE KLGTGENLAP WHPIKPGGVL ILGQEQDTVG GRFDATQAFV GELSQFNIWD RVLRAQEIVN IANCSTNMPG NIIPWVDNNV DVFGGASKWP VETCEERLLD L
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner.
基因功能參考文獻：
1. Neuronal pentraxin 2 predicts medial temporal atrophy and memory decline across the Alzheimer's disease spectrum. This research may advance the current understanding of Alzheimer's disease etiopathogenesis, while expanding early diagnostic techniques through the use of novel pro-inflammatory biomarkers, such as NPTX2. PMID: 27444967
2. NPTX2 in human cerebrospinal fluid is reduced in subjects with Alzheimer's disease and shows robust correlations with cognitive performance and hippocampal volume. PMID: 28440221
3. Decreased NPTX2 expression in rectal adenocarcinomas is associated with improved response to neoadjuvant chemoradiation and improved prognosis. PMID: 27083956
4. we show that NPTX2 is a marker of poor prognosis for neuroblastoma patients. PMID: 26294210
5. NPTX2 is overexpressed specifically in ccRCC primary tumors. PMID: 24962026
6. NPTX2 repressed NF-kappaB activity by inhibiting AKT through a p53-PTEN-dependent pathway, thus explaining the hypermethylation and downregulation of NPTX2 in NF-kappaB-activated high-risk glioblastomas. PMID: 24078801
7. Promoter methylation of NPTX2 is associated with glioblastoma. PMID: 23624749
8. Detection of aberrant methylation of NPTX2 in pure pancreatic juice samples could be useful as a molecular marker to discriminate between patients with malignant and benign disease of the pancreas PMID: 23360791
9. The visual cortex of NARP-deficient transgenic mice is hyperexcitable and unable to express ocular dominance, although many aspects of visual function are unimpaired. PMID: 23889936
10. This study showed that the NPTX2 protein is down-regulated in human primary pancreatic cancers and in pancreatic cancer cell lines. PMID: 22806544
11. This study demonistrated that childhood-onset mood disorders and suicide attempt association between HOMER1 rs2290639 and between NPTX2 markers rs705315 and rs1681248. PMID: 22460132
12. Demonstrate for the first time that NARP mutation significantly enhances apoptotic death as a result of three distinct lethal mitochondrial apoptotic insults including oxidative, Ca(2+), and lipid stress. PMID: 21812817
13. Data indicate that the aberrantly methylated NPTX2 gene may help to distinguish between chronic pancreatitis and pancreatic cancer with conventional diagnostic tools and could become a valuable diagnostic marker. PMID: 21778928
14. NPTX2, as a tumor-suppressor, plays an anti-tumor effect on pancreatic cancer and its low expression, due to promoter hypermethylation, may play a role in the tumorigenesis of pancreatic cancer. PMID: 21161403
15. study tested for the association of four SNPs of NPTX2 & haplotypes consisting of the SNPs with autism, between autistic patients & controls in a Japanese population; no significant difference was observed in allele, genotype or haplotype frequencies PMID: 17408830
16. pancreatic cancer cytology samples had statistically significant higher levels of NPTX2 methylation compared with benign diseases PMID: 17895837
17. Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies. PMID: 17987278
18. Homoplasmic cybrids harboring the 8993T-->G NARP mutation were also protected from death (75% vs 15% survival at 72 hours) by the supplemented medium and their ATP content was similar to controls PMID: 19667215
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亞細胞定位：

Secreted.
組織特異性：

Brain, pancreas, liver, heart and skeletal muscle. Highest levels are seen in the testis.
數據庫鏈接：

HGNC: 7953

OMIM: 600750

KEGG: hsa:4885

STRING: 9606.ENSP00000265634

UniGene: Hs.3281