Recombinant Human Microtubule-associated protein 6 (MAP6), partial

中文名稱：

人MAP6重組蛋白
貨號：

CSB-YP013441HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人MAP6重組蛋白
貨號：

CSB-EP013441HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人MAP6重組蛋白
貨號：

CSB-EP013441HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人MAP6重組蛋白
貨號：

CSB-BP013441HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人MAP6重組蛋白
貨號：

CSB-MP013441HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

MAP6
Uniprot No.：

Q96JE9
別名：

FLJ41346; KIAA1878; MAP 6; MAP-6; MAP6; MAP6_HUMAN; Microtubule associated protein 6; Microtubule-associated protein 6; MTAP6; N STOP; Stable tubule only polypeptide; Stable tubule-only polypeptide; STOP
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B. Regulates KIF5A-mediated axonal cargo transport. Regulates axonal growth during neuron polarization.
基因功能參考文獻：
1. the concentration of STOP/MAP6 protein was significantly reduced in the plasma of autistic subjects than that in healthy controls. PMID: 27541346
2. These data show that TMEM106B/MAP6 interaction is crucial for controlling dendritic trafficking of lysosomes, presumably by acting as a molecular brake for retrograde transport. PMID: 24357581
3. Structural basis for the association of MAP6 protein with microtubules and its regulation by calmodulin. PMID: 23831686
4. MAP6 might serve as a temperature sensor adapting its conformation according to the temperature to maintain the cellular microtubule network in organisms exposed to temperature decrease. PMID: 22904321
亞細胞定位：

Cytoplasm, cytoskeleton. Golgi apparatus. Cell projection, axon. Cell projection, dendrite. Cytoplasmic vesicle, secretory vesicle membrane; Lipid-anchor; Cytoplasmic side.
蛋白家族：

STOP family
組織特異性：

Expressed in brain (at protein level). Expressed in spinal cord. Isoform 2 expression is up-regulated in the prefrontal cortex (Brodmann's area 46) of patients with schizophrenia (postmortem brain study).
數據庫鏈接：

HGNC: 6868

OMIM: 601783

KEGG: hsa:4135

STRING: 9606.ENSP00000307093

UniGene: Hs.585540