Recombinant Human Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI1), partial

中文名稱：

人MAGI1重組蛋白
貨號：

CSB-YP857014HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人MAGI1重組蛋白
貨號：

CSB-EP857014HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人MAGI1重組蛋白
貨號：

CSB-EP857014HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人MAGI1重組蛋白
貨號：

CSB-BP857014HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人MAGI1重組蛋白
貨號：

CSB-MP857014HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

MAGI1
Uniprot No.：

Q96QZ7
別名：

AIP 3; AIP-3; AIP3; Atrophin 1 interacting protein 3; Atrophin-1-interacting protein 3; BAI1 associated protein 1; BAI1-associated protein 1; BAIAP 1; BAIAP1; BAP 1; BAP-1; BAP1; Gukmi1; MAGI 1; MAGI-1; MAGI1; MAGI1_HUMAN; MAGI1c; Membrane associated guanylate kinase inverted 1; membrane associated guanylate kinase WW and PDZ domain containing 1; Membrane-associated guanylate kinase; Membrane-associated guanylate kinase inverted 1; TNRC 19; TNRC19; Trinucleotide repeat containing gene 19; Trinucleotide repeat containing gene 19 protein; Trinucleotide repeat-containing gene 19 protein; WW and PDZ domain-containing protein 1; WW domain containing protein 3; WW domain-containing protein 3; WWP 3; WWP3
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface.
基因功能參考文獻：
1. Decreased MAGI1 expression in the colonic mucosa might contribute to the pathogenesis of microscopic colitis. PMID: 29204743
2. it negatively controls the cell growth of various types of cells and positively controls cell-cell interaction and the decreased expression of MAGI-1 in human T cells contributes to the development of several types of T-cell leukemia, partly through the stimulation of the Akt and MEK pathways. PMID: 29043551
3. Study presented a combined molecular dynamics/infrared spectroscopy approach to the study of ligand binding (11-residue peptide derived from the C terminus of HPV16 E6) by the PDZ1 domain of MAGI1, focusing in particular on the far-infrared region of the spectrum. PMID: 28636914
4. Here we present the result of a 4-stage genome-wide association study composed of 5,953 adolescent idiopathic scoliosis patients and 8,137 controls. Overall, we identified three novel susceptible loci including rs7593846 at 2p14 near MEIS1 , rs7633294 at 3p14.1 near MAGI1 and rs9810566 at 3q26.2 near TNIK PMID: 28334814
5. A deletion at ADAMTS9-MAGI1 locus is associated with psoriatic arthritis risk. PMID: 25990289
6. MAGI1 rs35855737 is a novel locus for neuroticism. [Meta-Analysis] PMID: 25993607
7. Variants in MAGI1 were associated with a Crohn's disease phenotype involving a complicated stricturing disease course. PMID: 25557950
8. The data suggests that inactivation of MAGI-1 by the NS1 protein from avian influenza A virus elicits an interferon-beta induction signal. PMID: 22911767
9. The PDZ1 and PDZ3 domains of MAGI-1 regulate the eight-exon isoform of the CXADR-like membrane protein. PMID: 22718816
10. MAGI1 may inhibit the cancer cell migration and invasion of hepatocellular carcinoma via regulating PTEN. PMID: 21685691
11. Results presented herein provide further evidence for a role of MAGI1 in bipolar affective disorder and schizophrenia etiology. PMID: 22381734
12. MAGI1 expression is decreased in hepatocellular carcinoma, which correlates with poor prognosis, suggesting MAGI1 as a novel prognostic marker PMID: 21942217
13. HPV16 E6 association with PDZ domain-containing proteins, MAGI1, Dlg1 or Scrib, stabilized the levels of E6. PMID: 21489588
14. Mutations designed in the C-terminal flanking region of the human MAGI-1 PDZ domain resulted in a significant decrease in binding affinity for human papillomavirus E6 peptides. PMID: 21238461
15. These results demonstrate that oncogenic HPV E6 proteins disrupt cellular tight junctions through the degradation of MAGI-1. PMID: 21123374
16. Data conclude that the up-regulation of sdk-1 in podocytes is an important pathogenic factor in glomerulosclerosis and that the mechanism involves disruption of the actin cytoskeleton possibly via alterations in MAGI-1 function. PMID: 20562105
17. interaction with synaptopodin and alpha-actinin-4 PMID: 12042308
18. Dll1 is presented on the surface of AJs formed at the apical termini of processes through interaction with MAGI1 to activate Notch on neighboring cells in the developing central nervous system PMID: 15908431
19. In vitro binding assays using the partial cDNA as a GST fusion protein confirm the binding to full-length MAGI-1 expressed in HEK293 cells. PMID: 16019084
20. MAGI-1 is important for vascular endothelial-cadherin-dependent Rap1 activation upon cell-cell contact. PMID: 16339077
21. MAGI-1 cleavage appears to be an important step in the disassembly of cell-cell contacts during apoptosis. PMID: 17191119
22. Structural basis for controlling the dimerization and stability of the WW domains of MAGI1 is reported. PMID: 18562638
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亞細胞定位：

Cell junction, tight junction. Cell membrane; Peripheral membrane protein. Note=Localizes to epithelial cells tight junctions.
組織特異性：

Widely expressed with the exception of skeletal muscle. Isoform 1, isoform 2 and isoform 6 are highly expressed in colon, kidney, lung, liver, and pancreas. Isoform 5 is predominantly expressed in brain and heart. Isoform 3 and isoform 4 are highly expres
數據庫鏈接：

HGNC: 946

OMIM: 602625

KEGG: hsa:9223

STRING: 9606.ENSP00000385450

UniGene: Hs.476636