Recombinant Human Matrilin-3 (MATN3)

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中文名稱：

人MATN3重組蛋白
品名簡(jiǎn)稱：

Recombinant Human MATN3 protein
貨號(hào)：

CSB-EP013522HU
說(shuō)明書：

MSDS Datasheet
規(guī)格：

￥1836
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

MATN3
Uniprot No.：

O15232
別名：

AV009181; DIPOA; EDM5; HOA; MATN3; MATN3_HUMAN; Matrilin 3; Matrilin-3; OADIP; OS2
種屬：

Homo sapiens (Human)
蛋白長(zhǎng)度：

Full Length of Mature Protein
來(lái)源：

E.coli
分子量：

57.2 kDa
表達(dá)區(qū)域：

29-486aa
氨基酸序列

DPVARPGFRRLETRGPGGSPGRRPSPAAPDGAPASGTSEPGRARGAGVCKSRPLDLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVKIEFQLQAYTDKQSLKQAVGRITPLSTGTMSGLAIQTAMDEAFTVEAGAREPSSNIPKVAIIVTDGRPQDQVNEVAARAQASGIELYAVGVDRADMASLKMMASEPLEEHVFYVETYGVIEKLSSRFQETFCALDPCVLGTHQCQHVCISDGEGKHHCECSQGYTLNADKKTCSALDRCALNTHGCEHICVNDRSGSYHCECYEGYTLNEDRKTCSAQDKCALGTHGCQHICVNDRTGSHHCECYEGYTLNADKKTCSVRDKCALGSHGCQHICVSDGAASYHCDCYPGYTLNEDKKTCSATEEARRLVSTEDACGCEATLAFQDKVSSYLQRLNTKLDDILEKLKINEYGQIHR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged and C-terminal Myc-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Tris-based buffer，50% glycerol
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.
基因功能參考文獻(xiàn)：
1. miR-448 contributed to the progression of osteoarthritis by directly targeting matrilin-3. PMID: 29483929
2. Study confirmed that MATN3 protein was highly expressed in GAC patients, and MATN3 overexpression could be used as an independent predictor of poor prognosis in GAC patients. PMID: 29343680
3. our results revealed miR-483-5p directly targeted to the cartilage matrix protein matrilin 3 (Matn3) and tissue inhibitor of metalloproteinase 2 (Timp2) to stimulate chondrocyte hypertrophy, extracellular matrix degradation, and cartilage angiogenesis, and it consequently initiated and accelerated the development of OA. PMID: 28139355
4. The results of the study indicate a potential role for the MATN3 rs28598872 polymorphism in the pathogenesis of Temporomandibular Joint Internal Derangement. PMID: 27533128
5. This report is the first to show the involvement of MATN3 in C-type natriuretic peptide/natriuretic peptide receptor-B signaling pathway during the process of transforming growth factor-beta induced chondrogenic differentiation of mesenchymal stem cells. PMID: 24934313
6. MATN3 plays a regulatory role in cartilage homeostasis due to its capacity to induce IL-1Ra, upregulate gene expression of major cartilage matrix components, and downregulate the expression of OA-associated matrix-degrading proteinases in chondrocytes. PMID: 22967398
7. MATN3 may have the inherent ability to inhibit premature chondrocyte hypertrophy by suppressing BMP-2/Smad1 activity PMID: 25331953
8. The VWA1 domain of matrilin-3 is primarily responsible for the induction of IL-6 release from primary human chondrocytes. PMID: 23523902
9. Polymorphism in the MATN3 gene might play a role in osteoarthritis in the Chinese Han population. PMID: 22973175
10. Haplotype-4 of MATN3 is associated with vertebral fracture risk independent of bone mineral density in Chinese postmenopausal women. PMID: 22270056
11. MATN3 mutations were identified in 13 multiple epiphyseal dysplasia patients and comprised predominantly of missense mutations. PMID: 21922596
12. Radiographic findings in patients with COMP and MATN3 mutations showed marked abnormalities in hip and knee joints. PMID: 21965141
13. a matrilin-3 mutation associated with osteoarthritis does not affect collagen affinity but promotes the formation of wider cartilage collagen fibrils PMID: 20077500
14. increased expression of MATN3 in osteoarthritis might contribute to the degeneration of articular cartilage. PMID: 18759284
15. potential of matrilin-3 to modulate gene expression profile of primary chondrocytes; tested matrilin3-dependent induction of pro-inflammatory cytokines, inducible nitric oxide synthetase & cyclooxygenase-2, MMP1, -3 & -13, & matrilin-3 itself PMID: 19840795
16. Mutation in MATN3 had significant association for patients with osteoarthritis. PMID: 12736871
17. Four novel missense mutations and one recurrent missense mutation were identified in MATN3 in seven families with multiple epiphyseal dysplasia. PMID: 14729835
18. MATN3 mutations is associated with multiple epiphyseal dysplasia PMID: 14994237
19. Contrary to the previous assumption that the MATN3 mutation in multiple epiphyseal dysplasia is confined to the beta-sheet regions, one novel mutation is located outside the beta-sheet region, within an alpha-helix region PMID: 15459972
20. COMP, type IX collagen and MATN3 play important roles in matrix assembly PMID: 15694129
21. mutations in matrilin-3 causing chondrodysplasias (R116W and C299S) interfere with intracellular protein trafficking and formation of filamentous extracellular structures PMID: 16199550
22. Multiple epiphyseal dysplasia caused by MATN3 mutations is the result of an intracellular retention of the mutant protein. PMID: 16287128
23. Patients carrying the T(303)M mutation in the gene for matrilin-3 express a form of HOA that is radiologically indistinguishable from idiopathic HOA in individual patients but they have more severe thumb-base involvement, particularly in the STT joint. PMID: 16641049
24. We have demonstrated intergenic splicing between two sets of family genes, the matrilin-3 (MATN3) and lysosomal-associated protein transmembrane 4alpha (LAPTM4A). PMID: 16769693
25. recombinant ADAMTS-4 effectively cleaved intact matrilin-3 at the predicted motif at Glu435/Ala436 generating two species of 45 and 5 kDa PMID: 17311924
26. a matn3 mutation causes decreased chondrocyte proliferation and dysregulated apoptosis leading to epiphyseal dysplasia PMID: 17517694
27. the matrilin-3 A-domain appears to bind exclusively to the COL3 domain of type IX collagen and this binding is abolished in the presence of a disease causing mutation in type IX collagen PMID: 17881354
28. The characterization of two additional alpha-helical mutations (p.Ala173Asp and p.Lys231Asn) is described. Both p.Phe105Ser and pAla173Asp prevent the secretion of A-domain in vitro. PMID: 18205203
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相關(guān)疾病：

Multiple epiphyseal dysplasia 5 (EDM5); Spondyloepimetaphyseal dysplasia MATN3-related (SEMD-MATN3); Osteoarthritis 2 (OS2)
亞細(xì)胞定位：

Secreted.
組織特異性：

Expressed only in cartilaginous tissues, such as vertebrae, ribs and shoulders.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 6909

OMIM: 140600

KEGG: hsa:4148

STRING: 9606.ENSP00000383894

UniGene: Hs.656199