Recombinant Human Liprin-alpha-4 (PPFIA4)

中文名稱：

人PPFIA4重組蛋白
貨號：

CSB-YP018440HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人PPFIA4重組蛋白
貨號：

CSB-EP018440HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人PPFIA4重組蛋白
貨號：

CSB-EP018440HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人PPFIA4重組蛋白
貨號：

CSB-BP018440HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人PPFIA4重組蛋白
貨號：

CSB-MP018440HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

PPFIA4
Uniprot No.：

O75335
別名：

KIAA0897; LIPA4_HUMAN; Liprin alpha 4; Liprin-alpha-4; PPFIA 4; PPFIA4; Protein tyrosine phosphatase receptor type f polypeptide (PTPRF) interacting protein (liprin) alpha 4; Protein tyrosine phosphatase receptor type f polypeptide interacting protein alpha 4; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4; PTPRF interacting protein alpha 4; PTPRF-interacting protein alpha-4
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區域：

1-701
氨基酸序列

MGSAADVRFS LGTTTHAPPG VHRRYSALRE ESAKDWETSP LPGMLAPAAG PAFDSDPEIS DVDEDEPGGL VGSADVVSPS GHSDAQTLAM MLQEQLDAIN EEIRMIQEEK ESTELRAEEI ETRVTSGSME ALNLKQLRKR GSIPTSLTAL SLASASPPLS GRSTPKLTSR SAAQDLDRMG VMTLPSDLRK HRRKLLSPVS REENREDKAT IKCETSPPSS PRTLRLEKLG HPALSQEEGK SALEDQGSNP SSSNSSQDSL HKGAKRKGIK SSIGRLFGKK EKGRLIQLSR DGATGHVLLT DSEFSMQEPM VPAKLGTQAE KDRRLKKKHQ LLEDARRKGM PFAQWDGPTV VSWLELWVGM PAWYVAACRA NVKSGAIMSA LSDTEIQREI GISNALHRLK LRLAIQEMVS LTSPSAPPTS RTSSGNVWVT HEEMETLETS TKTDSEEGSW AQTLAYGDMN HEWIGNEWLP SLGLPQYRSY FMECLVDARM LDHLTKKDLR VHLKMVDSFH RTSLQYGIMC LKRLNYDRKE LEKRREESQH EIKDVLVWTN DQVVHWVQSI GLRDYAGNLH ESGVHGALLA LDENFDHNTL ALILQIPTQN TQARQVMERE FNNLLALGTD RKLDDGDDKV FRRAPSWRKR FRPREHHGRG GMLSASAETL PAGFRVSTLG TLQPPPAPPK KIMPEAHSHY LYGHMLSAFR D
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
基因功能參考文獻：
1. The results identify PP1IFA4 loci associated with early onset atrial fibrillation in a Korean population. PMID: 28460022
2. Data show that liprin-alpha4 plays a pivotal role in inducing malignant phenotypes such as increased proliferation and invasion in pancreatic cancer, and that liprin-alpha4 could be a new effective therapeutic target for pancreatic cancer. PMID: 29187440
3. presence of Liprin-alpha4 and nickel increased tyrosine phosphatase activity that reduced the global levels of tyrosine phosphorylation in the cell PMID: 21829649
4. liprin-alpha4 is a hypoxia-induced gene potentially involved in cell-cell adhesion PMID: 20599943
亞細胞定位：

Cytoplasm. Cell surface.
蛋白家族：

Liprin family, Liprin-alpha subfamily
組織特異性：

Expressed only in the heart, brain, and skeletal muscle.
數據庫鏈接：

HGNC: 9248

OMIM: 603145

KEGG: hsa:8497

UniGene: Hs.153648