Recombinant Human Latexin (LXN)

中文名稱：

人LXN重組蛋白
貨號：

CSB-YP013240HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人LXN重組蛋白
貨號：

CSB-EP013240HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人LXN重組蛋白
貨號：

CSB-EP013240HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人LXN重組蛋白
貨號：

CSB-BP013240HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人LXN重組蛋白
貨號：

CSB-MP013240HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

LXN
Uniprot No.：

Q9BS40
別名：

ECI; Endogenous carboxypeptidase inhibitor; Latexin; Latexin protein; LXN; LXN_HUMAN; MUM; Protein MUM; TCI; Tissue carboxypeptidase inhibitor
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-222
氨基酸序列

MEIPPTNYPA SRAALVAQNY INYQQGTPHR VFEVQKVKQA SMEDIPGRGH KYHLKFAVEE IIQKQVKVNC TAEVLYPSTG QETAPEVNFT FEGETGKNPD EEDNTFYQRL KSMKEPLEAQ NIPDNFGNVS PEMTLVLHLA WVACGYIIWQ NSTEDTWYKM VKIQTVKQVQ RNDDFIELDY TILLHNIASQ EIIPWQMQVL WHPQYGTKVK HNSRLPKEVQ LE
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation.
基因功能參考文獻：
1. Results identified that LXN expression inversely modulates taxane-chemoresistance in the PC-3 prostate cancer cell line. Inhibition of LXN expression in the bone microenvironment promotes chemoresistance, in part through a methylation-dependent mechanism. PMID: 28087740
2. Results show that Lxn expression was clearly decreased in the pancreatic ductal adenocarcinoma tissues suggesting it that as a tumor suppressor that targets CD133-positive cancer cells. PMID: 26530530
3. Lxn protein and mRNA expression levels in CD133+ miapaca-2 cells were significantly lower than those in CD133- cells. PMID: 25551472
4. latexin is markedly downregulated in hepatocellular carcinoma specimens, compared to adjacent non-cancerous tissues. PMID: 24399246
5. CD146 and Lxn increased tumor migration and invasion of thyroid cancer. PMID: 23712706
6. The hematopoietic stem cell regulatory gene latexin has tumor-suppressive properties in malignant melanoma. PMID: 23364479
7. These results are consistent with a tumor suppressor role for latexin. PMID: 23028717
8. Latexin expression is lost or greatly reduced in approximately 50% of human leukemia/lymphoma cell lines. PMID: 21567403
9. downregulated expression in gastric carcinomas; tumor suppressor PMID: 21466706
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亞細胞定位：

Cytoplasm.
蛋白家族：

Protease inhibitor I47 (latexin) family
組織特異性：

Highly expressed in heart, prostate, ovary, kidney, pancreas, and colon, moderate or low in other tissues including brain.
數據庫鏈接：

HGNC: 13347

OMIM: 609305

KEGG: hsa:56925

STRING: 9606.ENSP00000264265

UniGene: Hs.478067