Recombinant Human Killer cell immunoglobulin-like receptor 2DS2 (KIR2DS2), partial
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中文名稱：人KIR2DS2重組蛋白
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貨號：CSB-EP012360HU1-B
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說明書：
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規格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產品詳情
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純度：>85% (SDS-PAGE)
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基因名：
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Uniprot No.：
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別名：KIR2DS2; CD158J; NKAT5; Killer cell immunoglobulin-like receptor 2DS2; CD158 antigen-like family member J; MHC class I NK cell receptor; NK receptor 183 ActI; Natural killer-associated transcript 5; NKAT-5; p58 natural killer cell receptor clone CL-49; p58 NK receptor CL-49; CD antigen CD158j
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種屬：Homo sapiens (Human)
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蛋白長度：Partial
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蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式：Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產品評價
相關產品
靶點詳情
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功能：Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.
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基因功能參考文獻：
- Genotypes missing these two inhibitory KIR-HLA combinations in addition to missing activating KIRs 2DS2 and 2DS3 were more common in Vogt-Koyanagi-Harada disease (OR = 1.90, P = 0.002). PMID: 27490240
- KIR2DS2/HLA-C1 may correlate with Hashimoto thyroiditis in a Chinese population. PMID: 27042744
- Loss of KIR2DS2 gene is associated with breast cancer. PMID: 27631728
- association between KIR2DS2 and the response to methotrexate (MTX), moreover, the combination KIR2DL2+/KIR2DS2+ was more frequent in responders to MTX (p = 0.043). PMID: 27251940
- this study shows that the presence of KIR2DS2 was associated with a worsening of haematopoietic stem cell transplantation from HLA-matched sibling donor for treatment of myeloid malignancies PMID: 27394130
- genetic polymorphism is associated with childhood acute lymphoblastic leukemia among north Indians PMID: 26472014
- this study was to look for immunogenetic determinants in the pathogenesis of FMF and find out if KIR are related to susceptibility. An activator KIR gene, KIR2DS2, was significantly more frequent in FMF patients (p=0.036). PMID: 26574972
- a significant increase in the frequency of KIR2DL2 (P = 0.019) as well as KIR2DS2 (P = 0.008) in patients with neuroblastoma compared with the healthy control group, was found. PMID: 26202659
- Single Nucleotide Polymorphism in KIR2DS2 gene is associated with Asthma and Atopic Dermatitis. PMID: 26430804
- genetic polymorphism is associated with chronic hepatitis C and levels of viremia in Poland PMID: 25636579
- KIR2DL2 and KIR2DS2 genotype is associated with protection against primary biliary cirrhosis in Han population. PMID: 25575065
- CD4(+) CD28(-) cells exhibited increased KIR2DS2, reduced KIR2DL3 and increased DAP12 expression in HD-ESRD compared with NDD-CKD patients. PMID: 25484131
- Authors showed a significant increased correlation between KIR2DL2/DS2, type 2 diabetes and HLA-C1C1 genotype in the type 2 diabetes patients infected with human herpesvirus 8. PMID: 24122895
- NK cells with KIR2DS2 immunogenotype have a functional activation advantage to efficiently kill glioblastoma and prolong animal survival. PMID: 25381437
- There is an association of the KIR2DS gene, especially KIR2DS2, with psoriatic arthritis. PMID: 24185760
- Activating killer cell immunoglobulin-like receptor 2DS2 binds to HLA-A*11. PMID: 24550293
- Analysis of this large cohort from Uganda in the context of other African populations reveals variations in KIR and HLA-C1 and C2 that are consistent with migrations within Africa and potential selection pressures on these genes. PMID: 23974321
- Data indicate that increased frequency of the activating receptor KIR2DS1 and a reduced frequency of the KIR-ligand combination KIR2DS2/2DL2 absent/C1 present were significantly associated with chronic myeloid leukemia (CML). PMID: 23380384
- presence of KIR2DS2 is associated with rheumatoid arthritis. PMID: 22960345
- Our data revealed a unique contribution of activating KIRs (KIR2DS4, KIR2DS2, or KIR3DS1), in addition to NKG2C, in the expansion of human natural killer cells. PMID: 23325834
- in response to HCT therapy, the activating receptors are also enhanced by a process that increases the number of unmethylated sites present on KIR2DS2/4 promoters. PMID: 22939905
- The frequency of the combination of HLA-C1 allele group with KIR2DS2 was significantly higher in severe dry eye disease patients. PMID: 22509813
- individuals possessing KIR2DL2 and/or KIR2DS2 (and, in most cases, also KIR2DL1) gene but no HLA-C C2 ligand may respond better to treatment and survive longer than people bearing other genotypes. PMID: 22836042
- KIR2DS2/KIR2DL2 and HLA-C genotype of rheumatoid arthritis patients may provide predictive information for response to anti-TNF-alpha therapy. PMID: 21373785
- In a comparison of healthy controls and a tightly defined cohort of adult ITP patients, the KIR2DS2/KIR2DL2 genotype was found to be associated with ITP independently of FCGR3a-158 polymorphisms. PMID: 22024796
- The CMV seropositivity of donors was not associated with activating KIR expression, and donor null expression in those with the KIR2DS2 or KIR2DS4 genotype was not predictive for CMV reactivation in the recipient. PMID: 21596150
- This study showed a significantly lower frequency of KIR2DS2 among chronic HCV carriers compared with controls in a Korean population PMID: 22065905
- KIR2DS2*005 encodes a molecule expressed on the surface of natural killer- and T-lymphocytes. PMID: 21593779
- predisposition to systemic lupus erythematosus was associated with GTGT deletion at the SLC11A1 3'UTR, presence of KIR2DS2 +/KIR2DS5 +/KIR3DS1 + profile, increased number of stimulatory KIR genes and European and Amerindian ancestries PMID: 21233146
- indicated nonspecific stimulation of natural killers, probably mediated by an increase in serum concentration of heat shock protein with a molecular weight of 70 kDa PMID: 21165439
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20878400
- an evolutionary trend toward reducing the avidity of the activating C1- and C2-specific receptors is exempllified by KIR2DS2, an activating C1-specific receptor that has lost all detectable avidity for HLA class I. PMID: 20802150
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20528243
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20580654
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20600442
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20643584
- Observational study of genotype prevalence. (HuGE Navigator) PMID: 20650299
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20652381
- Observational study of genotype prevalence. (HuGE Navigator) PMID: 20670355
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20137308
- Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20356536
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20371502
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20426625
- Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20483367
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20492596
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20519398
- Single nucleotide polymorphism in KIR2DS2 gene is associated with posttransplantation non-Hodgkin lymphoma. PMID: 20207982
- Observational study of gene-disease association. (HuGE Navigator) PMID: 19683555
- Observational study of gene-disease association. (HuGE Navigator) PMID: 19968064
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20082482
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亞細胞定位：Cell membrane; Single-pass type I membrane protein.
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蛋白家族：Immunoglobulin superfamily
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