Recombinant Human Insulin receptor-related protein (INSRR), partial

中文名稱：

人INSRR重組蛋白
貨號：

CSB-YP011755HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人INSRR重組蛋白
貨號：

CSB-EP011755HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人INSRR重組蛋白
貨號：

CSB-EP011755HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人INSRR重組蛋白
貨號：

CSB-BP011755HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人INSRR重組蛋白
貨號：

CSB-MP011755HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

INSRR
Uniprot No.：

P14616
別名：

INSRR; INSRR_HUMAN; Insulin Receptor R; Insulin receptor related receptor precursor; Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain; insulin receptor-related receptor; IR R; IR related receptor; IR-related receptor; IRR; Sir r; Sirr
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.
基因功能參考文獻：
1. the extensive glycosylation of FnIII-2/3 provides steric hindrance for the alkali-induced rearrangement of the IRR ectodomain. PMID: 29156593
2. IRR activation involves two separate centers of pH-dependent rearrangements that act synergistically to induce a major conformational change in the IRR molecule, resulting in internal kinase domains rapprochement and autophosphorylation. PMID: 25597417
3. IRR activation is not based on a single residue deprotonation in the IRR ectodomain but rather involves synergistic conformational changes at multiple points. PMID: 24121506
4. Insulin receptor-related receptor as an extracellular pH sensor involved in the regulation of acid-base balance. (Review) PMID: 23220417
5. Analysis of structural determinants of alkali sensor IRR positive cooperativity. PMID: 23824460
6. IRR mRNA expression was found in 25 (51%) neuroblastomas and correlated with stages 1, 2, 3, and 4S disease and with age. PMID: 14654552
7. Phosphotyrosine detection revealed a lack in the constitutive activation of the IRR described for analogous constructs of the two other members of the family PMID: 15629149
8. The IRR gene is expressed in the same ovarian compartment, IRR mRNA content increases strikingly in these cells in the afternoon of the first proestrus. PMID: 16195402
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
數據庫鏈接：

HGNC: 6093

OMIM: 147671

KEGG: hsa:3645

STRING: 9606.ENSP00000357178

UniGene: Hs.248138