Recombinant Human Homeobox protein VENTX (VENTX)

中文名稱：

人VENTX重組蛋白
貨號(hào)：

CSB-YP528513HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人VENTX重組蛋白
貨號(hào)：

CSB-EP528513HU-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人VENTX重組蛋白
貨號(hào)：

CSB-BP528513HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人VENTX重組蛋白
貨號(hào)：

CSB-MP528513HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

VENTX
Uniprot No.：

O95231
別名：

hemopoietic progenitor homeobox protein VENTX2; Homeobox protein VENTX; HPX42B; MGC119910; MGC119911; NA88A; VENT homeobox homolog; VENT like homeobox 2; VENT like homeobox protein 2; VENT-like homeobox protein 2; VENTX; VENTX_HUMAN; VENTX2
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-258
氨基酸序列

MRLSSSPPRG PQQLSSFGSV DWLSQSSCSG PTHTPRPADF SLGSLPGPGQ TSGAREPPQA VSIKEAAGSS NLPAPERTMA GLSKEPNTLR APRVRTAFTM EQVRTLEGVF QHHQYLSPLE RKRLAREMQL SEVQIKTWFQ NRRMKHKRQM QDPQLHSPFS GSLHAPPAFY STSSGLANGL QLLCPWAPLS GPQALMLPPG SFWGLCQVAQ EALASAGASC CGQPLASHPP TPGRPSLGPA LSTGPRGLCA MPQTGDAF
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

May be involved in ventralization.
基因功能參考文獻(xiàn)：
1. Findings suggest potential applications of homeobox protein VentX (VentX)-regulated tumor-associated macrophages (TAMs) in cancer immunotherapy. PMID: 29872044
2. VENTX impairs expression of genes involved in erythroid differentiation and is highly expressed in patients with acute erythroid leukemia. PMID: 27888632
3. VentX induces apoptosis of cancer cells in a p53-independent manner PMID: 27175592
4. Data suggest that homeobox transcription factor VentX may be a target to modulate Dendritic cells (DCs) functions and manage inflammatory diseases. PMID: 24706756
5. VentX regulates critical cell cycle regulators and Wnt downstream genes previously implicated in HSC/MPP proliferation and expansion. PMID: 22791709
6. Results provide mechanistic insight into the crucial roles of VentX in macrophage differentiation and proinflammatory activation and suggest that dysregulation of VentX may play a role in the pathogenesis of autoimmune diseases. PMID: 21670496
7. Data show that VentX is a direct transcriptional activator of p53-p21 and p16ink4a-Rb tumor suppression pathways. PMID: 21325273
8. these data extend our insights into the function of embryonic mesodermal factors in human postnatal hematopoiesis and indicate a role for VENTX in normal and malignant myelopoiesis. PMID: 20833819
9. a potential role of VentX in the clinical behavior of hematopoietic malignancies. PMID: 20028861
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亞細(xì)胞定位：

Nucleus.
組織特異性：

Expressed in bone marrow of patients recovering from chemotherapy. Also expressed in an erythroleukemia cell line.
數(shù)據(jù)庫鏈接：

HGNC: 13639

OMIM: 607158

KEGG: hsa:27287

STRING: 9606.ENSP00000357556

UniGene: Hs.125231