Recombinant Human Heat shock 70 kDa protein 1-like (HSPA1L)

中文名稱：

人HSPA1L重組蛋白
貨號：

CSB-YP010823HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人HSPA1L重組蛋白
貨號：

CSB-EP010823HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人HSPA1L重組蛋白
貨號：

CSB-EP010823HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人HSPA1L重組蛋白
貨號：

CSB-BP010823HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人HSPA1L重組蛋白
貨號：

CSB-MP010823HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

HSPA1L
Uniprot No.：

P34931
別名：

Heat shock 70 kDa protein 1 Hom ; Heat shock 70 kDa protein 1 like ; Heat shock 70 kDa protein 1-Hom; Heat shock 70 kDa protein 1-like; Heat shock 70 kDa protein 1L; Heat shock 70kD protein like 1; HS71L_HUMAN; HSP70 1L; HSP70 HOM ; HSP70-Hom; HSPA1L; hum70t; Spermatid specific heat shock protein 70
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區域：

1-641
氨基酸序列

MATAKGIAIG IDLGTTYSCV GVFQHGKVEI IANDQGNRTT PSYVAFTDTE RLIGDAAKNQ VAMNPQNTVF DAKRLIGRKF NDPVVQADMK LWPFQVINEG GKPKVLVSYK GENKAFYPEE ISSMVLTKLK ETAEAFLGHP VTNAVITVPA YFNDSQRQAT KDAGVIAGLN VLRIINEPTA AAIAYGLDKG GQGERHVLIF DLGGGTFDVS ILTIDDGIFE VKATAGDTHL GGEDFDNRLV SHFVEEFKRK HKKDISQNKR AVRRLRTACE RAKRTLSSST QANLEIDSLY EGIDFYTSIT RARFEELCAD LFRGTLEPVE KALRDAKMDK AKIHDIVLVG GSTRIPKVQR LLQDYFNGRD LNKSINPDEA VAYGAAVQAA ILMGDKSEKV QDLLLLDVAP LSLGLETAGG VMTALIKRNS TIPTKQTQIF TTYSDNQPGV LIQVYEGERA MTKDNNLLGR FDLTGIPPAP RGVPQIEVTF DIDANGILNV TATDKSTGKV NKITITNDKG RLSKEEIERM VLDAEKYKAE DEVQREKIAA KNALESYAFN MKSVVSDEGL KGKISESDKN KILDKCNELL SWLEVNQLAE KDEFDHKRKE LEQMCNPIIT KLYQGGCTGP ACGTGYVPGR PATGPTIEEV D
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Positive regulator of PRKN translocation to damaged mitochondria.
基因功能參考文獻：
1. HSP70-HOM gene polymorphism associated with susceptibility to noise-induced hearing loss. PMID: 29072670
2. In a cohort of youth at risk for bipolar disorder, pathway analysis showed an enrichment of the glucocorticoid receptor (GR) pathway with the genes MED1, HSPA1L, GTF2A1 and TAF15, which might underlie the previously reported role of stress response in the risk for bipolar disorder in vulnerable populations. PMID: 28291257
3. A heterozygous de novo mutation (c.830C > T; p.Ser277Leu) in HSPA1L in ulcerative colitis patient. Five additional rare HSPA1L mutations (p.Gly77Ser, p.Leu172del, p.Thr267Ile, p.Ala268Thr, p.Glu558Asp) were found in six other patients. All six rare HSPA1L variant proteins showed decreased chaperone activity in vitro. Moreover, three variants demonstrated dominant negative effects on HSPA1L and HSPA1A protein activity. PMID: 28126021
4. Polymorphism of HSPA1L gene is associated with the development of esophageal Carcinoma. PMID: 26745065
5. may be a predictive biomarker for chronic graft-versus-host disease following allogeneic stem cell transplantation PMID: 25680846
6. HSPA1L (rs2227956) is associated with a decreased risk of idiopathic pulmonary fibrosis in a Mexican population. PMID: 26496868
7. Infertility in males with normal sperm parameters was not significantly associated with HSPA1L:c.1478C>T gene polymorphism. PMID: 26160076
8. HSP70-hom polymorphisms modify the association of diethylhexyl phthalates exposure with insulin resistance. PMID: 25044062
9. In HSPA1L T2437C polymorphisms, there was no significant differences in frequencies of the variant homozygous in patients compared to controls. PMID: 23666708
10. findings show polymorphisms of HSP70 genes are associated with the development of gastric cancer and duodenal ulcers in a population at high risk for gastric cancer in Costa Rica PMID: 24051039
11. studied the relationship between blood levels of HSP70 and HSP90 and genotypes of HSP70, GSTT1, and GSTM1 polymorphic variants in individuals chronically exposed to mercury PMID: 23330093
12. HSP70-hom gene polymorphism may have a role in graft-versus-host disease after hematopoietic stem cell transplantation PMID: 17060867
13. examined the relationship between the HSP70-hom polymorphism and the clinical characteristics of the malignancy at the time of diagnosis PMID: 17578680
14. A strong association was found between HSP-70/Hom rs2075800 G and uveitis in patients with sarcoidosis. PMID: 17591867
15. polymorphisms in HSP70-HOM genes associated with noise-induced hearing loss PMID: 18813331
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蛋白家族：

Heat shock protein 70 family
組織特異性：

Expressed in spermatids.
數據庫鏈接：

HGNC: 5234

OMIM: 140559

KEGG: hsa:3305

STRING: 9606.ENSP00000364805

UniGene: Hs.690634