Recombinant Human Follicular dendritic cell secreted peptide (FDCSP)

中文名稱：

人FDCSP重組蛋白
貨號：

CSB-YP854120HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人FDCSP重組蛋白
貨號：

CSB-EP854120HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人FDCSP重組蛋白
貨號：

CSB-EP854120HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人FDCSP重組蛋白
貨號：

CSB-BP854120HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人FDCSP重組蛋白
貨號：

CSB-MP854120HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

FDCSP
Uniprot No.：

Q8NFU4
別名：

C4orf7; FDC secreted protein; FDC-SP; FDCSP; FDSCP_HUMAN; Follicular dendritic cell secreted peptide; Follicular dendritic cell secreted protein
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區域：

18-85
氨基酸序列

FPV SQDQEREKRS ISDSDELASG FFVFPYPYPF RPLPPIPFPR FPWFRRNFPI PIPESAPTTP LPSEK
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Can bind to the surface of B-lymphoma cells, but not T-lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.
基因功能參考文獻：
1. These studies show that TNF-alpha stimulates human FDC-SP gene transcription by targeting YY1, GATA, C/EBP2 and C/EBP3 in the FDC-SP gene promoter. PMID: 29356241
2. LPS-induced upregulation of FDC-SP expression in human periodontal ligament cells may enhance osteoclastogenesis in periodontal disease. PMID: 26577469
3. FDC-SP may be involved in IgA production in the tonsils of Immunoglobulin A nephropathy patients. PMID: 25953661
4. FDC-SP overexpression inhibits osteogenic differentiation of hPDLCs. study contributes to a better understanding of biological functions governing FDC-SP-induced hPDLC differentiation. PMID: 24138099
5. Our findings demonstrate that transfection with FDC-SP has negligible adverse effect on proliferation of hPDLCs and imply the biological function of FDC-SP as a fibroblastic phenotype stabilizer PMID: 24357406
6. The role of C4orf7 in ovarian cancer cell morphology, motility and invasion was demonstrated. PMID: 20811673
7. FDC-SP has a very restricted tissue distribution, expressed by activated FDCs from tonsils and TNF-alpha-activated FDC-like cell lines, but not by B cell lines, primary germinal center B cells, or anti-CD40 plus IL-4-activated B cells. PMID: 12193705
8. Since only normal tissue was examined, these findings suggest that FDC-SP plays an important but previously unsuspected role within oral connective tissue. PMID: 16259954
9. These results provide the first evidence for immunomodulatory activities of FDC-SP and implicate this molecule as a regulator of B cell responses. PMID: 17548624
顯示更多

收起更多
亞細胞定位：

Secreted.
組織特異性：

Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon.
數據庫鏈接：

HGNC: 19215

OMIM: 607241

KEGG: hsa:260436

STRING: 9606.ENSP00000318437

UniGene: Hs.733448