Recombinant Human Fascin-2 (FSCN2)

中文名稱：

人FSCN2重組蛋白
貨號：

CSB-YP009011HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人FSCN2重組蛋白
貨號：

CSB-EP009011HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人FSCN2重組蛋白
貨號：

CSB-EP009011HU-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人FSCN2重組蛋白
貨號：

CSB-BP009011HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人FSCN2重組蛋白
貨號：

CSB-MP009011HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

FSCN2
Uniprot No.：

O14926
別名：

Fascin homolog 2; actin bundling protein; retinal Strongylocentrotus purpuratus; Fascin Strongylocentrotus purpuratus homolog 2 actin bundling protein; retinal; Fascin-2; FSCN2; FSCN2_HUMAN; Retinal fascin; RFSN; RP30
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達(dá)區(qū)域：

1-492
氨基酸序列

MPTNGLHQVL KIQFGLVNDT DRYLTAESFG FKVNASAPSL KRKQTWVLEP DPGQGTAVLL RSSHLGRYLS AEEDGRVACE AEQPGRDCRF LVLPQPDGRW VLRSEPHGRF FGGTEDQLSC FATAVSPAEL WTVHLAIHPQ AHLLSVSRRR YVHLCPREDE MAADGDKPWG VDALLTLIFR SRRYCLKSCD SRYLRSDGRL VWEPEPRACY TLEFKAGKLA FKDCDGHYLA PVGPAGTLKA GRNTRPGKDE LFDLEESHPQ VVLVAANHRY VSVRQGVNVS ANQDDELDHE TFLMQIDQET KKCTFYSSTG GYWTLVTHGG IHATATQVSA NTMFEMEWRG RRVALKASNG RYVCMKKNGQ LAAISDFVGK DEEFTLKLIN RPILVLRGLD GFVCHHRGSN QLDTNRSVYD VFHLSFSDGA YRIRGRDGGF WYTGSHGSVC SDGERAEDFV FEFRERGRLA IRARSGKYLR GGASGLLRAD ADAPAGTALW EY
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.
基因功能參考文獻(xiàn)：
1. diffuse expression in 82% of undifferentiated/dedifferentiated endometrial carcinomas PMID: 28272224
2. Tax-mediated transcriptional induction of Fascin requires NF-kappaB- and TRR-dependent promoter activation, and a promoter-independent, but PP2-sensitive signaling pathway. PMID: 26363219
3. the serum fascin level is an effective indicator of tumor aggressiveness, and that it plays an important role in the prognosis of NSCLC, particularly for non-distant metastatic patients. PMID: 24070574
4. Data indicate the specific contribution of fascin and cortactin during invadopodium formation. PMID: 24414419
5. The filopodium: a stable structure with highly regulated repetitive cycles of elongation and persistence depending on the actin cross-linker fascin PMID: 21975552
6. Fascin expression predicts survival after potentially curative resection of node-positive colon cancer. PMID: 20410808
7. The 208delG mutation in the FSCN2 gene produces not only autosomal dominant retinitis pigmentosa but also ADMD (autosomal dominant macular degeneration) PMID: 14609921
8. The photoreceptor-specific FSCN2 gene showed a relatively high number of sequence variations. PMID: 16280978
9. The 208delG mutation in FSCN2 is not associated with hereditary retinal degeneration in the Chinese individuals examined. PMID: 17251446
10. Real-time PCR-based genotyping method developed here is useful for investigations of allelic asymmetries within genomic regions with variations found in retinitis pigmentosa and retinl degeneration. PMID: 18450588
11. In ovarian tumors fascin is associated with certain features of increased tumor aggressiveness. PMID: 18498068
12. Higher fascin scores correlated positively with tumor differentiation of esophageal SqCC. Significantly worse prognosis in patients with high scores of fascin, poor differentiation, T4 stage, positive for lymph node metastasis and distant metastasis PMID: 19207554
13. expression may play an essential role in regulation of progression of oral squamous cell carcinoma and contributes to the event of epithelial-mesenchymal transition in the early aggressiveness of OSCC PMID: 19473443
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相關(guān)疾病：

Retinitis pigmentosa 30 (RP30)
亞細(xì)胞定位：

Cytoplasm, cytoskeleton. Cell projection, stereocilium.
蛋白家族：

Fascin family
組織特異性：

Localized specifically in the outer and inner segments of the photoreceptor cells in the retina.
數(shù)據(jù)庫鏈接：

HGNC: 3960

OMIM: 607643

KEGG: hsa:25794

STRING: 9606.ENSP00000334665

UniGene: Hs.118555