Recombinant Human Dual specificity protein phosphatase 9 (DUSP9)

中文名稱：

人DUSP9重組蛋白
貨號：

CSB-YP859528HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人DUSP9重組蛋白
貨號：

CSB-EP859528HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人DUSP9重組蛋白
貨號：

CSB-EP859528HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人DUSP9重組蛋白
貨號：

CSB-BP859528HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人DUSP9重組蛋白
貨號：

CSB-MP859528HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

DUSP9
Uniprot No.：

Q99956
別名：

Dual specificity phosphatase 9; Dual specificity protein phosphatase 9; DUS9_HUMAN; DUSP9; MAP kinase phosphatase 4; Mitogen activated protein kinase phosphatase 4; Mitogen-activated protein kinase phosphatase 4; MKP 4; MKP-4; MKP4; serine/threonine specific protein phosphatase
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-384
氨基酸序列

MEGLGRSCLW LRRELSPPRP RLLLLDCRSR ELYESARIGG ALSVALPALL LRRLRRGSLS VRALLPGPPL QPPPPAPVLL YDQGGGRRRR GEAEAEAEEW EAESVLGTLL QKLREEGYLA YYLQGGFSRF QAECPHLCET SLAGRAGSSM APVPGPVPVV GLGSLCLGSD CSDAESEADR DSMSCGLDSE GATPPPVGLR ASFPVQILPN LYLGSARDSA NLESLAKLGI RYILNVTPNL PNFFEKNGDF HYKQIPISDH WSQNLSRFFP EAIEFIDEAL SQNCGVLVHC LAGVSRSVTV TVAYLMQKLH LSLNDAYDLV KRKKSNISPN FNFMGQLLDF ERSLRLEERH SQEQGSGGQA SAASNPPSFF TTPTSDGAFE LAPT
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Inactivates MAP kinases. Has a specificity for the ERK family.
基因功能參考文獻：
1. The results of this study, combined with previous studies, suggested that therapeutic intervention to increase the expression or activity of DUSP9 may enable the activation of anti-proliferation signals in malignant cells. PMID: 25998184
2. A possible use for DUSP9 as CIMP marker. PMID: 24838152
3. DUSP9 protein levels were markedly suppressed in severe pre-eclampsia, but not in severe IUGR. This suppression might be attributable to the prolonged hypoxic conditions found in pre-eclampsia. PMID: 23276385
4. The DUSP9 locus is a common susceptibility locus for type 2 diabetes across different ethnicities, and 6 loci identified in South Asian genome-wide association studies also have significant effect on susceptibility to Japanese type 2 diabetes. PMID: 23029454
5. decreased expression of DUSP-9 is associated with poor prognosis in ccRCC. PMID: 21943117
6. 2.7 A resolution crystal structure of the catalytic domain of MKP-4 (MKP-4C) is presented PMID: 21206059
7. microtubule disruption by MKP4 provides a novel mechanism for tumor suppression by a cytosolic MKP PMID: 18006813
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亞細胞定位：

Cytoplasm.
蛋白家族：

Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
數據庫鏈接：

HGNC: 3076

OMIM: 300134

KEGG: hsa:1852

STRING: 9606.ENSP00000345853

UniGene: Hs.144879